909566-58-1Relevant articles and documents
Compositions and methods for the treatment of epilepsy
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Page/Page column 37, (2016/04/20)
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, trigeminal neuralgia, attention-deficit hyperactivity disorder, partial seizures, adjunctive therapy for partial, myoclonic, tonic-clonic seizures and schizophrenia, neuropathic pain, seizures, Tourette syndrome, Alzheimer's disease, autism, bipolar disorder and anxiety disorder, bipolar disorder, mania, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder, myotonia congenita and post-traumatic stress disorder.
An alternate synthesis of enantiomerically pure levetiracetam (Keppra)
Mujahid, M.,Mujumdar, P.,Sasikumar, M.,Kunte, S. S.,Muthukrishnan, M.
, p. 1512 - 1515,4 (2012/12/12)
A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.
An alternate synthesis of enantiomerically pure levetiracetam (Keppra)
Mujahid,Mujumdar,Sasikumar,Kunte,Muthukrishnan
, p. 1512 - 1515 (2013/01/15)
A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (>99%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up.
Chiral oxazolidinones as electrophiles: Intramolecular cyclization reactions with carbanions and preparation of functionalized lactams
Gibson, Sarah,Jacobs, Hollie K.,Gopalan, Aravamudan S.
, p. 887 - 890 (2011/03/18)
The intramolecular cyclizations of oxazolidinones with carbanions adjacent to sulfones, sulfoxides, and phosphonates proceed in high yields to obtain functionalized γ and δ lactams. The chiral oxazolidinone precursors can be readily synthesized from comme
Asymmetric synthesis of the antiepileptic drug levetiracetam
Imahori, Tatsushi,Omoto, Keisuke,Hirose, Yumi,Takahata, Hiroki
experimental part, p. 1627 - 1632 (2009/07/17)
Palladium-catalyzed asymmetric synthesis of levetiracetam of antiepileptic drug was expediently accomplished.
PROCESSES FOR THE PREPARATION OF LEVETIRACETAM
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Page/Page column 14, (2008/12/06)
Provided are processes for preparing levetiracetam of the Formula (I):Various aspects and embodiments are provided.
PROCESS FOR PREPARING LEVETIRACETAM
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Page/Page column 5; 7, (2008/06/13)
Process for the preparation of (S)-(-)-α-ethyl-2-oxo-l-pyrrolidineacetamide of Formula (I) by the steps of condensation of (S)-2-amino butanol of Formula (II) and 4-halobutryl chloride, where halo group can be chloro, bromo or iodo in solvents to form α-ethyl-2- oxo pyrrolidine ethanol of Formula (III); oxidation of (S)-α-ethyl-2-oxo pyrrolidine ethanol to yield (S)-α-ethyl-2-oxo pyrrolidine acetic acid having the formula (IV); esterification of (S)-α-ethyl-2-oxo pyrrolidine acetic acid (IV) with an alcohol to provide alkyl ester of Formula (V) wherein, R is 1-4 Carbon atom ; ammonolysis of alkyl esters of formula (V) with ammonia to provide (S)-(-)- α-ethyl-2-oxo-l -pyrrolidine acetamide of formula (I).
A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric α-aminooxylation
Kotkar, Shriram P.,Sudalai, Arumugam
, p. 6813 - 6815 (2007/10/03)
An efficient enantioselective synthesis of a new antiepileptic drug, levetiracetam is described, in high optical purity (>99.5% ee), using proline-catalyzed α-aminooxylation of n-butyraldehyde as the key step.
