- Zinc and Cadmium Complexes of Pyridinemethanol Carboxylates: Metal Carboxylate Zwitterions and Metal–Organic Frameworks
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The heterofunctional lactone furo[3,4-b]pyridin-5(7H)-one (L1) undergoes a coordination-induced ring-opening reaction with Zn(NO3)2 ? 6H2O to yield the zwitterionic [Zn(L1′)2(H2O)2] (1, L1′=2-(hydroxymethyl)nicotinate) with an uncoordinated carboxylate. The same reaction with Cd(NO3)2 ? 4H2O provides a two-dimensional (2D) network of [Cd(L1′)2]n (3) with the carboxylates coordinated to cadmium(II) propagating the assembly. The corresponding reactions of Zn(NO3)2 ? 6H2O and Cd(NO3)2 ? 4H2O with 2-(hydroxymethyl)isonicotinic acid (HL2) generated zwitterionic [Zn(L2)2(H2O)2] (2) and a 2D network [Cd(L2)2]n?nDMF (4, DMF=N,N′-dimethylformamide), respectively. Complexes 1–4 are weakly emissive, giving ligand-centered emissions at 409 nm (1), 412/436 nm (2), 404 nm (3), and 412/436 nm (4) in CHCl3 solutions upon excitation at 330 nm. This work points to the potential of using ‘hidden’ functionalities widely found in small organic molecules and natural products for the construction of coordination complexes with new functionality and potential applications.
- Lin, Shi-Xin,Liu, Quan,Liu, Yan,Niu, Ru-Jie,Young, David J.,Zhang, Wen-Hua
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p. 832 - 837
(2020/06/03)
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- Modular synthesis and biological activity of pyridyl-based analogs of the potent Class i Histone Deacetylase Inhibitor Largazole
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The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein.
- Clausen, Dane J.,Smith, William B.,Haines, Brandon E.,Wiest, Olaf,Bradner, James E.,Williams, Robert M.
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p. 5061 - 5074
(2015/08/03)
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- Isolation of first row transition metal-carboxylate zwitterions
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Zwitterionic 3d metal carboxylates of Zn(ii), Cu(ii), Ni(ii) and Co(ii) have been isolated and structurally authenticated by X-ray crystallography. A series of 2-hydroxymethylpyridine-carboxylate ligands with different sizes and shapes demonstrate variabl
- Armaghan, Mahsa,Lu, W. Y. James,Wu, Di,Wei, Yao,Yuan, Feng-Ling,Ng, Seik Weng,Amini, Mostafa M.,Zhang, Wen-Hua,Young, David J.,Hor, T. S. Andy,Lang, Jian-Ping
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p. 42978 - 42989
(2015/05/27)
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