923262-96-8

Basic information

• Product Name: SAR-407899
• Synonyms: SAR 407899;SAR407899;SAR-407899;6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride;6-(piperidin-4-yloxy)isoquinolin-1(2h)-one hcl;SAR407899 (hydrochloride);SAR407899 HCl;6-(4-Piperidinyloxy)-1(2H)-isoquinolinone hydrochloride
• CAS NO: 923262-96-8
• Molecular Formula: C14H17ClN2O2
• Molecular Weight: 280.74998
• Product Categories: API
• Mol File: 923262-96-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SAR-407899(CAS DataBase Reference)
• NIST Chemistry Reference: SAR-407899(923262-96-8)
• EPA Substance Registry System: SAR-407899(923262-96-8)

Safety Data

• Hazardous Substances Data: 923262-96-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SAR-407899 is used as a sleep-promoting agent for the treatment of sleep disorders. Its mechanism of action involves blocking the orexin receptor 1, which helps in regulating the sleep-wake cycle, thereby potentially improving sleep quality and duration in individuals suffering from sleep-related issues.
Used in Addiction Treatment:
In the field of addiction medicine, SAR-407899 is utilized as a therapeutic agent to address drug-seeking behavior and the risk of relapse. By antagonizing the orexin receptor 1, it may help in reducing cravings and the propensity for substance abuse, offering a potential new approach to addiction treatment and recovery support.
Research into SAR-407899 is ongoing, with the aim of further exploring its therapeutic potential in the management of sleep disorders and addiction, as well as identifying any additional applications where its unique mechanism of action could be beneficial.

Upstream product

• 1035922-94-1 C₂₇H₃₂N₂O₅ 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 147754-12-9 4-fluoro-2-methylbenzonitrile 
• 1417697-15-4 4-[4-cyano-3-((E)-2-pyrrolidin-1-yl-vinyl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED PHENYL COMPOUNDS

The present invention relates to novel substituted phenyl compounds of the formula (VI) and to a process for making them. The compounds can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone derivatives.

SUBSTITUTED PHENYL COMPOUNDS

The present invention relates to novel substituted phenyl compounds of the formula and to a process for making them. The compounds can be used as intermediates for making 6-substituted-1-(2H)-isoquinolinone derivatives.

PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES

The present invention relates to a process for making 6-substituted-1-(2H)- isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in th