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147754-12-9 Usage


4-Fluoro-2-methylbenzonitrile is an organic compound that exists as a white to light yellow crystalline powder. It is characterized by its chemical structure, which includes a benzene ring with a fluorine atom at the 4-position, a methyl group at the 2-position, and a nitrile group attached to the carbon at the 2-position.


Used in Pharmaceutical Industry:
4-Fluoro-2-methylbenzonitrile is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to serve as a building block in the development of new medications, potentially contributing to the treatment of various health conditions.
Used in Chemical Synthesis:
In the chemical industry, 4-Fluoro-2-methylbenzonitrile is utilized as an organic intermediate. Its versatile structure makes it a valuable component in the synthesis of a wide range of chemical products, including specialty chemicals, agrochemicals, and other industrial applications.
Overall, 4-Fluoro-2-methylbenzonitrile is a versatile compound with applications in both the pharmaceutical and chemical industries, primarily due to its unique chemical structure and its role as an intermediate in the synthesis of various products.

Check Digit Verification of cas no

The CAS Registry Mumber 147754-12-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,7,5 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147754-12:
149 % 10 = 9
So 147754-12-9 is a valid CAS Registry Number.

147754-12-9 Well-known Company Product Price

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  • Alfa Aesar

  • (H26641)  4-Fluoro-2-methylbenzonitrile, 97%   

  • 147754-12-9

  • 5g

  • 1362.0CNY

  • Detail
  • Alfa Aesar

  • (H26641)  4-Fluoro-2-methylbenzonitrile, 97%   

  • 147754-12-9

  • 25g

  • 5402.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 4-Fluoro-2-methylbenzonitrile

1.2 Other means of identification

Product number -
Other names 4-fluoro-2-methylbenzenecarbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147754-12-9 SDS

147754-12-9Relevant articles and documents

Practical CuCl/DABCO/4-HO-TEMPO-catalyzed oxidative synthesis of nitriles from alcohols with air as oxidant

Hu, Yongke,Chen, Lei,Li, Bindong

supporting information, p. 464 - 466 (2017/11/13)

A mild and efficient methodology for the direct oxidative synthesis of nitriles from easily available alcohols and aqueous ammonia by employing CuCl/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses the air as a green oxidant and aqueous ammonia as the nitrogen source at room temperature. A variety of aryl, heterocyclic and allylic alcohols are smoothly converted into the corresponding nitriles in good to excellent yields.

New trelagliptin preparation process


Paragraph 0033; 0034; 0035, (2016/10/17)

The present invention provides a trelagliptin preparation process, which comprises that: 1) a compound 4 and a compound 5 are adopted as raw materials, and are subjected to a condensation reaction in an organic solvent in the presence of an alkali to obtain a compound 6; 2) the compound 6 reacts with an acid HA in an organic solvent to remove the t-butyloxy carbonyl so as to obtain a trelagliptin.HA salt; and 3) the trelagliptin.HA salt is subjected to alkali neutralization treatment and purification to obtain the trelagliptin, wherein the reaction route is defined in the specification. According to the present invention, in the improved preparation process, the 2-site amino of the compound 5 is protected by the t-butyloxy carbonyl, such that the selectivity of the nucleophilic substitution reaction is improved, and the impurity production caused by primary amine substitution is avoided so as to improve the nucleophilic substitution yield and improve the trelagliptin purity.

Cobalt-Catalyzed Electrophilic Cyanation of Arylzinc Halides with N-Cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS)

Cai, Yingxiao,Qian, Xin,Rrat, Alice,Auffrant, Audrey,Gosmini, Corinne

supporting information, p. 3419 - 3423 (2016/01/25)

The cobalt-catalyzed cross-coupling of organozinc bromides with N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) is described. The same cobalt catalyst, cobalt(II) bromide, was used for both the synthesis of the organozinc species and the cross-coupling reaction. However in this case, a catalytic amount of zinc dust is necessary in the second step to release the low-valent cobalt. Under these mild conditions, moderate to excellent yields of different benzonitriles were obtained.

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