924307-76-6

Basic information

• Product Name: 8-Nonenoicacid,2-amino-,(2S)-
• Synonyms: 8-Nonenoicacid,2-amino-,(2S)-;(2S)-2-Amino-8-nonenoic acid;(S)-2-(6'-heptenyl)glycine;(2S)-2-aminonon-8-enoic acid
• CAS NO: 924307-76-6
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.24
• Product Categories: API
• Mol File: 924307-76-6.mol

Chemical Properties

• Melting Point: 200-201℃ (DEC.)
• Boiling Point: 303℃
• Flash Point: 137℃
• Appearance: /
• Density: 1.002
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.54±0.24(Predicted)
• CAS DataBase Reference: 8-Nonenoicacid,2-amino-,(2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nonenoicacid,2-amino-,(2S)-(924307-76-6)
• EPA Substance Registry System: 8-Nonenoicacid,2-amino-,(2S)-(924307-76-6)

Safety Data

• Hazardous Substances Data: 924307-76-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Nonenoicacid, 2-amino-, (2S)is used as a pharmaceutical intermediate for the synthesis of various bioactive compounds and drug candidates. Its unique structure and chirality may contribute to the development of novel therapeutic agents with improved efficacy and selectivity.
Used in Biochemistry Research:
8-Nonenoicacid, 2-amino-, (2S)serves as a valuable tool in biochemical research, enabling the investigation of enzyme specificity, protein-ligand interactions, and the role of chirality in biological systems. Its incorporation into peptides and other biomolecules can provide insights into the structure-function relationships of biologically relevant compounds.
Used in Organic Synthesis:
8-Nonenoicacid, 2-amino-, (2S)is utilized as a building block in organic synthesis, allowing the preparation of a wide range of chiral compounds with potential applications in various industries. Its nonenyl side chain and amino functionality can be further modified to access diverse chemical structures and functional groups.

Upstream product

• 4117-09-3 7-bromo-hept-1-ene 
• 924309-93-3 (±)-2-acetamido-8-nonenoic acid 

Downstream Products

• 769167-55-7 (S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid 
• 1058705-94-4 N-tert-butoxycarbonyl-2-amino-8-nonenoic acid dicyclohexylamine salt 
• 1315325-71-3 (2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide 
• 1315326-97-6 (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)non-8-enoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide 
• 1078627-32-3 (S)-2-((4-fluoro-phenyl)amino)-non-8-enoic acid 
• 1309889-23-3 C₂₈H₃₇BrN₄O₈S₂*ClH 
• 1309888-81-0 C₃₃H₄₅BrN₄O₁₀S₂ 
• 1309888-80-9 C₂₉H₃₆BrN₃O₈S 
• 1309888-79-6 C₂₉H₃₈BrN₃O₉S 
• 861397-55-9 C₃₀H₄₀BrN₃O₉S 
• 1309888-72-9 C₃₂H₄₄BrN₃O₉S 
• 1309889-22-2 C₃₃H₄₁BrN₆O₉S₂ 
• 300831-21-4 (S)-2-(tert-butoxycarbonylamino)non-8-enoic acid 

Relevant articles and documents

Process for the preparation of (S)-2-amino-non-8-enoic acid

Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.

Efficient synthesis of (S)-2-(cyclopentyloxycarbonyl)-amino-8-nonenoic acid: Key building block for BILN 2061, an HCV NS3 protease inhibitor

A new procedure for the practical synthesis of (S)-2-(cyclopen- tyloxycarbonyl)amino-8-nonenoic acid, a key building block for BILN 2061, an HCV NS3 protease inhibitor, has been developed. The key step features a kinetic resolution of racemic 2-acetylamino-8-nonenoic acid with acylase I. In addition, the undesired (R)-2-acetylamino-8-nonenoic acid was recycled after racemization. The procedure was implemented for the production of (S)-2-(cyclopentyloxycarbonyl)amino-8-nonenoic acid on pilot-plant scale.