cas 924307-76-6, 8-Nonenoicacid,2-amino-,(2S)- | Articles data ｜lookchem

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924307-76-6

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Process for the preparation of (S)-2-amino-non-8-enoic acid
Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.
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(2018/09/14)

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE
Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.
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(2016/09/22)

Efficient synthesis of (S)-2-(cyclopentyloxycarbonyl)-amino-8-nonenoic acid: Key building block for BILN 2061, an HCV NS3 protease inhibitor
A new procedure for the practical synthesis of (S)-2-(cyclopen- tyloxycarbonyl)amino-8-nonenoic acid, a key building block for BILN 2061, an HCV NS3 protease inhibitor, has been developed. The key step features a kinetic resolution of racemic 2-acetylamino-8-nonenoic acid with acylase I. In addition, the undesired (R)-2-acetylamino-8-nonenoic acid was recycled after racemization. The procedure was implemented for the production of (S)-2-(cyclopentyloxycarbonyl)amino-8-nonenoic acid on pilot-plant scale.
Wang, Xiao-Jun,Zhang, Li,Smith-Keenan, Lana L.,Houpis, Ioannis N.,Farina, Vittorio
p. 60 - 63
(2012/12/26)

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Chemical Properties

Melting Point: 200-201℃ (DEC.)
Boiling Point: 303℃
Flash Point:137℃
Density: 1.002
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
PKA: 2.54±0.24(Predicted)
PSA: 63.32000
LogP: 2.23510

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