930766-09-9

Basic information

• Product Name: CYCLOHEXANOL, 4-(4-CHLOROPHENYL)-
• Synonyms: 4-(4-CHLORO-PHENYL)-CYCLOHEXANOL;CYCLOHEXANOL, 4-(4-CHLOROPHENYL)-
• CAS NO: 930766-09-9
• Molecular Formula: C12H15ClO
• Molecular Weight: 210.702
• Mol File: 930766-09-9.mol

Chemical Properties

• Boiling Point: 325.2°C at 760 mmHg
• Flash Point: 150.5°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 9.53E-05mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• PKA: 15.15±0.40(Predicted)
• CAS DataBase Reference: CYCLOHEXANOL, 4-(4-CHLOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXANOL, 4-(4-CHLOROPHENYL)-(930766-09-9)
• EPA Substance Registry System: CYCLOHEXANOL, 4-(4-CHLOROPHENYL)-(930766-09-9)

Safety Data

• Hazardous Substances Data: 930766-09-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

InChI:InChI=1/C12H15ClO/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-2,5-6,10,12,14H,3-4,7-8H2

Upstream product

• 14472-80-1 4-(4-chlorophenyl)cyclohexan-1-one 
• 95233-37-7 trans-4-(p-chlorophenyl)cyclohexane carboxylic acid 
• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 637-87-6 1-Chloro-4-iodobenzene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 36716-71-9 4-(4-chlorophenyl)-4-hydroxycyclohexanone 

Downstream Products

• 215672-87-0 Oxalic acid mono-[4-(4-chloro-phenyl)-cyclohexyl] ester 

Relevant articles and documents

A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp3 carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interest as a target for inhibition due to its implication in neuropathic pain and respiratory disease. Herein, we describe the optimization of a series of potent, selective, and orally bioavailable TRPA1 small molecule antagonists, leading to the discovery of a novel tetrahydrofuran-based linker. Given the balance of physicochemical properties and strong in vivo target engagement in a rat AITC-induced pain assay, compound 20 was progressed into a guinea pig ovalbumin asthma model where it exhibited significant dose-dependent reduction of inflammatory response. Furthermore, the structure of the TRPA1 channel bound to compound 21 was determined via cryogenic electron microscopy to a resolution of 3 ?, revealing the binding site and mechanism of action for this class of antagonists.

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