954225-35-5 Usage
Uses
Used in Pharmaceutical Industry:
2-(Bromomethyl)-5-fluoropyridine is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Bromomethyl)-5-fluoropyridine is utilized as a precursor in the synthesis of compounds with pesticidal properties. Its incorporation into these products can enhance crop protection and contribute to more effective agricultural practices.
Used in Specialty Chemicals Production:
2-(Bromomethyl)-5-fluoropyridine also serves as a building block in the production of specialty chemicals. Its versatility in chemical reactions enables the creation of a wide range of chemical products with specific applications in various industries, such as materials science and chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 954225-35-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,4,2,2 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 954225-35:
(8*9)+(7*5)+(6*4)+(5*2)+(4*2)+(3*5)+(2*3)+(1*5)=175
175 % 10 = 5
So 954225-35-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BrFN/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,3H2
954225-35-5Relevant articles and documents
6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens
Rodríguez, Diana,Maneiro, María,Vázquez-Ucha, Juan C.,Beceiro, Alejandro,González-Bello, Concepción
, p. 3737 - 3755 (2020/04/30)
The ability of 6-(aryl)methylidene penicillin-based sulfones 1-7 to repurpose β-lactam antibiotics activity with bacterial species that carry carbapenem-hydrolyzing class D β-lactamases (OXA-23, OXA-24/40 and OXA-48), as well as with class A (TEM-1, CTX-M-2) and class C (CMY-2, DHA-1) enzymes, is reported. The combinations imipenem/3 and imipenem/4 restored almost completely the antibiotic efficacy in OXA-23 and OXA-24/40 carbapenemase-producing A. baumannii strains (1 μg mL-1) and also provided good results for OXA-48 carbapenemase-producing K. pneumoniae strains (4 μg mL-1). Compounds 2-6 in combinations with ceftazidime and ampicillin were also efficient in restoring antibiotic efficacy in E. coli strains carrying class C (CMY-2 and DHA-1) and class A (TEM-1 and CTX-M-2) β-lactamase enzymes, respectively. Kinetic and inhibition studies with the OXA-24/40 enzyme, protein mass spectrometry analysis and docking studies allowed us to gain an insight into the inhibition mechanism and the experimentally observed differences between the ligands.
