95897-49-7

Basic information

• Product Name: 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
• Synonyms: 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine;7-broMo-2H,3H-[1,4]dioxino[2,3-b]pyridine;7-Brom-pyridodioxen;1,4-Dioxino[2,3-b]pyridine, 7-bromo-2,3-dihydro-
• CAS NO: 95897-49-7
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216
• Mol File: 95897-49-7.mol

Chemical Properties

• Boiling Point: 272.472 °C at 760 mmHg
• Flash Point: 118.587 °C
• Appearance: /
• Density: 1.691 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.42±0.20(Predicted)
• CAS DataBase Reference: 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine(95897-49-7)
• EPA Substance Registry System: 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine(95897-49-7)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 95897-49-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine is utilized as a key intermediate in the synthesis of various drugs and pharmaceutical products. Its unique structure and properties contribute to the development of novel therapeutic agents.
Used in Research and Development:
7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine also holds potential in research and development for the creation of new chemical compounds and materials. Its exploration can lead to advancements in various scientific and industrial applications, further expanding its utility and significance in the field of chemistry.

Upstream product

• 34206-49-0 5-bromo-2,3-dihydroxy-pyridine 
• 106-93-4 ethylene dibromide 
• 16867-04-2 dihydroxypyridine 
• 129421-32-5 2,3-dihydro-1,4-dioxino<2,3-b>pyridine 

Downstream Products

• 1256818-31-1 2,3-dihydro-[1,4]-dioxino[2,3-b]pyridine-7-carboxylic acid 
• 95849-26-6 2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-7-carbaldehyde 
• 1356165-72-4 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro[1,4]dioxino[2,3-b]pyridine 

Relevant articles and documents

AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS

The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer, reducing inflammation and/or treating an autoimmune or inflammatory disease.

DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF

The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3- dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlogumine; and use of the derivatives and analogs for treating cancer.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

New Positive allosteric modulators of nicotinic acetylcholine receptor

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.