960298-00-4

Basic information

• Product Name: 2-(Benzyloxy)-4-bromopyridine
• Synonyms: 2-(Benzyloxy)-4-bromopyridine
• CAS NO: 960298-00-4
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.1179
• Mol File: 960298-00-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-(Benzyloxy)-4-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzyloxy)-4-bromopyridine(960298-00-4)
• EPA Substance Registry System: 2-(Benzyloxy)-4-bromopyridine(960298-00-4)

Safety Data

• Hazardous Substances Data: 960298-00-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(Benzyloxy)-4-bromopyridine is used as a building block for the synthesis of complex organic molecules. Its presence facilitates the creation of diverse chemical structures, which can be further modified or functionalized to achieve desired properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(Benzyloxy)-4-bromopyridine is utilized as a key intermediate in the development of new pharmaceuticals. Its unique structure allows for the design of compounds with specific biological activities, contributing to the discovery of novel therapeutic agents.
Used in Pharmaceutical Development:
2-(Benzyloxy)-4-bromopyridine is employed as a precursor in the synthesis of pharmaceuticals. Its functional groups and bromine atom enable the production of compounds with potential therapeutic applications, including those targeting various diseases and conditions.
Used in Agrochemical Development:
2-(Benzyloxy)-4-bromopyridine also finds application in the agrochemical industry, where it is used as a starting material for the synthesis of agrochemicals. Its versatility and reactivity make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals.
Used in Chemical Research and Development:
2-(Benzyloxy)-4-bromopyridine is a valuable asset in chemical research, where it is used to explore new reaction pathways and develop innovative synthetic methods. Its unique properties and reactivity provide researchers with opportunities to investigate novel chemical transformations and applications.

Upstream product

• 100-39-0 benzyl bromide 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 100-51-6 benzyl alcohol 
• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 73583-37-6 2-chloro-4-bromopyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 1214900-01-2 2-(benzyloxy)pyridin-4-amine 

Downstream Products

• 1423175-51-2 2-(benzyloxy)-4-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)thio)phenyl)pyridine 
• 1423175-52-3 2-(benzyloxy)-4-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)sulfinyl)phenyl)pyridine 
• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 1624283-59-5 N-benzyl-2-(benzyloxy)pyridin-4-amine 
• 1624283-57-3 2-(benzyloxy)-N-(3-ethylphenyl)pyridin-4-amine 
• 1624283-58-4 2-(Benzyloxy)-N-(4-methoxyphenyl)pyridin-4-amine 
• 1624283-49-3 2-[4-(4-methoxyphenylamino)-2-oxo-2H-pyridin-1-yl]-N-isopentylacetamide 

Relevant articles and documents

GPR40 AGONISTS

This disclosure is directed, at least in part, to GPR40 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR40 agonists are gut-restricted compounds. In some embodiments, the GPR40 agonists are full agonists or partial agonists. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).

THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS

Thienopyridone compounds of formula (I) or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

New compounds, pharmaceutical compositions and uses thereof

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

5H-PYRROLO[3,4-￡>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β- amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

ANTIVIRAL COMPOUNDS

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position oxopyridine or lsoquinolone and having the formula (I): wherein., S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

RENIN INHIBITORS

The present invention relates to piperidinyl-based renin inhibitor compounds having the formula containing amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.