98382-93-5

Basic information

• Product Name: 3-nitropyridine-4-thiol
• Synonyms: 3-nitropyridine-4-thiol;3-nitro-4-Pyridinethiol
• CAS NO: 98382-93-5
• Molecular Formula: C₅H₄N₂O₂S
• Molecular Weight: 156.16246
• Mol File: 98382-93-5.mol

Chemical Properties

• Melting Point: 190 °C (decomp)
• Boiling Point: 285.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.457±0.06 g/cm3(Predicted)
• PKA: 7.84±0.18(Predicted)
• CAS DataBase Reference: 3-nitropyridine-4-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitropyridine-4-thiol(98382-93-5)
• EPA Substance Registry System: 3-nitropyridine-4-thiol(98382-93-5)

Safety Data

• Hazardous Substances Data: 98382-93-5(Hazardous Substances Data)

Upstream product

• 98130-83-7 3-nitro-4-thiocyanato-pyridine 
• 141-52-6 sodium ethanolate 
• 13091-23-1 4-chloro-3-nitropyridine 
• 108-96-3 4-pyridone 
• 5435-54-1 4-hydroxy-3-nitropyridine 

Downstream Products

• 855940-59-9 2-(3-nitro-[4]pyridylmercapto)-1-phenyl-ethanone 
• 273-75-6 thiazolo[4,5-c]pyridine 
• 503321-47-9 10H-dipyrido[3,4-b:3',4'-e][1,4]thiazine 
• 5028-26-2 3-nitro-4-(N,N-dimethylamino)pyridine 
• 503321-46-8 1,4-dithiino[2,3-c;6,5-c']dipyridine 
• 831-20-9 1,4-dithiino[2,3-c;5,6-c']dipyridine 
• 164406-91-1 3-aminopyridine-4-sulfonamide 
• 856848-67-4 4-isopentylmercapto-[3]pyridylamine 

Relevant articles and documents

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

Synthesis and structure of dipyrido-1,4-dithiins

Synthesis, properties and reactions of two isomeric dipyrido-1,4-dithiins of the C2h and C2v symmetry are described. Their structure determination and identification are based on spectroscopic methods (1H and 13C NMR, HETCOR, gHMBC and MS), physical properties (mp and Rf), the 1,4-dithiin ring opening reactions and finally X-Ray analysis. A very unusual type of the Smiles rearrangement (S→S, the pyridyl group migrates from one sulfur atom to another) during the 1,4-dithiin ring opening with sodium methanethiolate enabling isomerization of dithiin with the C2h symmetry to dithiin with the C2v symmetry is found.

Synthesis of pyrido-1,2,4-thiadiazines related to antihypertensive 1,2,4-benzothiadiazine-1,1-dioxides

Oxidation of 3-phenyl-2H-pyrido[2,3-e]-1,2,4-thiadiazine with sodium hypochlorite and, separately, m-chloroperoxybenzoic acid afforded a 1,1- dioxide and a 5-oxide derivative, respectively. Further examples of such 1,1- dioxide derivatives were synthesised by treating 2-amino-5-methylpyridine with orthoesters and these were subsequently oxidised to novel 1,1,5- trioxides. A short route has been developed for the synthesis of 4- aminopyridine-3-sulfonamide which was used for the preparation of 4H- pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides; oxidation of the parent member of the series gave a 1,1,7-trioxide derivative. 3-Aminopyridine-4-sulfonamide has been prepared, and then condensed with triethyl orthoformate to afford 4H-pyrido[3,4-e]-1,2,4-thiadiazine 1,1-dioxide.