98717-15-8

Basic information

• Product Name: Ropivacaine hydrochloride
• Synonyms: ROPIVCACAINE HYDROCHLORIDE;ROPIVACAINE HCL;(S)-ROPIVACAINE HYDROCHLORIDE;S-ROPIVACAINE HCL;n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride;Ropivacaine mesilate;Ropivacaine hydrochloride;(2S)-N-(2,6-dimethylphenyl)-1-propyl-pipecolinamide hydrochloride
• CAS NO: 98717-15-8
• Molecular Formula: C₁₇H₂₆N₂O*ClH
• Molecular Weight: 310.86
• EINECS: 1312995-182-4
• Product Categories: Active Pharmaceutical Ingredients;Anesthetic (Local)
• Mol File: 98717-15-8.mol

Chemical Properties

• Melting Point: 260-262°
• Boiling Point: 436.7 °C at 760 mmHg
• Flash Point: 217.9 °C
• Appearance: /
• Density: 1.044 g/cm³
• Vapor Pressure: 4.37E-08mmHg at 25°C
• CAS DataBase Reference: Ropivacaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ropivacaine hydrochloride(98717-15-8)
• EPA Substance Registry System: Ropivacaine hydrochloride(98717-15-8)

Safety Data

• Hazardous Substances Data: 98717-15-8(Hazardous Substances Data)

Usage

Uses

2-Piperidinecarboxamide hydrochloride is a useful research chemical compound.

Definition

ChEBI: The anhydrous form of (S)-ropivacaine hydrochloride.

InChI:InChI=1/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H

Upstream product

• 65797-42-4 (+/-)-2',6'-pipecoloxylidide hydrochloride 
• 106-94-5 propyl bromide 
• 84057-95-4 ropivacaine 
• 1236222-96-0 propyl (1-propylpiperidine)-2-carboxylate 
• 87-62-7 2,6-dimethylaniline 
• 3105-95-1 pipecolinic acid 
• 4043-87-2 pipecolic Acid 
• 926275-68-5 (S)-1-propylpiperidine-2-carboxylic acid 

Downstream Products

• 132112-35-7 ropivacaine hydrochloride monohydrate 
• 84057-95-4 ropivacaine 

Relevant articles and documents

Industrial preparation method of ropivacaine hydrochloride monohydrate

The invention discloses an industrial synthesis method of ropivacaine hydrochloride monohydrate. The method comprises the following steps: dissolving racemized 2-piperidinecarboxylic acid serving as a starting material in an organic solvent, and carrying out alkylation reaction, transesterification, chiral resolution and salification refining to obtain a target product. The raw materials are cheap and easy to obtain, a one-pot method is adopted, organic reagents are easy to recycle and reuse, the reaction safety coefficient is high, the technological operation is simple, few three wastes are generated, and the obtained ropivacaine hydrochloride monohydrate is high in yield and high in purity.

Method for preparing ropivacaine hydrochloride

The preparation method comprises the following specific steps: 1) reacting (S)- piperidine -2 - formic acid with propionaldehyde in the presence of a reducing agent and an aprotic solvent to obtain the intermediate 1. 2). N. NIn the presence of -dimethylformamide and an aprotic solvent, the intermediate 1 obtained in step 1) and the acylating agent are subjected to an acylation reaction to give an intermediate 2. 3). N. N[-] The intermediate 2 obtained in step 2) and 2 and 6 -dimethylaniline are subjected to a condensation reaction in the presence of dimethylformamide and basic conditions to give an intermediate 3. 4) The intermediate 3 obtained in step 3) is salified with hydrochloric acid to give the ropivacaine hydrochloride crude product. 5) The ropivacaine hydrochloride is purified to obtain ropivacaine hydrochloride. The method has the advantages that the product purity is higher than 99.99%, the synthesis process is mild in reaction condition, simple in preparation process, low in cost, safe and environment-friendly, and is suitable for industrial production.

Preparation method of ropivacaine hydrochloride

The invention discloses a preparation method of ropivacaine hydrochloride. The preparation method comprises steps as follows: (1) preparation of an intermediate (I), (2) preparation of an intermediate (II), (3) preparation of a crude product and (4) refin

PROCESS FOR ENANTIOMERIC ENRICHMENT OF 2 ', 6 ' - PIPECOLOXYLIDIDE

The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel intermediates formed in the process of enantiomeric enrichment of 2',6'-pipecoloxylidide, preparation of N- substituted amidic acids and alkylation of 2',6'-pipecoloxylidide.

PROCESS FOR PRODUCING OPTICALLY ACTIVE N-ALKYL-PIPERIDINE-2-CARBOXANILIDE

Disclosed herein is a process for producing optically active 1-n-propyl-2',6'-dimethyl-2-piperidinecarboxanilide. The process comprises of reacting n-propyl pipecolate ester with 2,6-dimethylanilino magnesium halide. The 1-n-propyl-2',6'-dimethyl-2-piperi

PROCESS FOR THE PREPARATION OF (S)-ROPIVACAINE HYDROCHLORIDE MONOHYDRATE

Process for preparation of Ropivacaine hydrochloride monohydrate comprising resolution of racemic pipecoloxylidide in non-ketonic solvents to give (S)-pipecoloxylidide followed by N-propylation to in water ass reaction medium give (S)-Ropivacaine base; co

ROPIVACAINE HYDROCHLORIDE ANHYDRATE AND THE PREPARATION THEREOF

The invention pertains to a process for preparing stable anhydrous Ropivacaine hydrochloride, the process involving preparing Ropivacaine hydrochloride from Ropivacaine base, wherein Ropivacaine base is provided having a chiral purity of more than 95 %, a

A PROCESS FOR THE PREPARATION OF AN INJECTABLE SOLUTION OF (2S)-N-(2;6-DIMETHYL-PHENYL)-1-PROPYL-2-PIPERIDINCARBOXAMIDE

A process for the preparation of an injectable solution of (2S)-(-)-N- (2;6-dimethyl-phenyl)-l-propyl-2-piperidincarboxamide (Ropivacaine) starting from Ropivacaine base substantially free from the dextro enantiomer, by dissolution of the same in water fo

Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom

The present invention describes a novel process of preparation of optically pure L-Pipecolic acid and an improved process for the conversion of L-pipecolic acid to L-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, its hydrochloride salt and hydrochloride monohydrate.