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All total 20 Articles be foundA Continuous Flow Process for the Synthesis of Hymexazol
Ma, Xin-Peng,Chen, Jin-Sha,Du, Xiao-Hua
, p. 1152 - 1158 (2019)
Hymexazol is an efficient and low-toxicity soil fungicide. In this work, a fully continuous flow process for the synthesis of hymexazol has been developed. This process begins with combining ethyl acetoacetate and hydroxylamine hydrochloride to form a hydroxamic acid intermediate. The reaction solution is then quenched with concentrated hydrochloric acid to obtain the final product, hymexazol. Under the optimized process conditions, the total yield of the target product reached 86%. In addition, production was successfully scaled-up to a kilogram scale. The continuous flow method not only greatly decreases the reaction time but also significantly inhibits the side reactions.
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Goeth,H. et al.
, p. 137 - 142 (1967)
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Photoactivatable AMPA for the study of glutamatergic neuronal transmission using two-photon excitation
Asad, Naeem,Deodato, Davide,Dore, Timothy M.
supporting information, p. 5589 - 5594 (2021/07/02)
We report a photoactivatable agonist of the AMPA subtype of ionotropic glutamate receptors, TMP-CyHQ-AMPA, which was designed to study the fast excitatory transmission between neurons. Upon visible light excitation, TMP-CyHQ-AMPA quantitatively released AMPA in high quantum yield on an ultra-short timescale. Intriguingly, the photolyisis can be carried out using 2-photon excitation (2PE) with remarkable efficiency, giving a two-photon uncaging action cross section (δu) value of 1.71 GM. TMP-CyHQ-AMPA is soluble in pysiological buffer and no hydrolysis was detected in the absence of light. Molecular docking experiments indicated that the photocaging strategy abolishes the affinity of AMPA for the GluR2 receptor and no GABAergic effects (as commonly observed in caged glutamates) are expected. TMP-CyHQ-AMPA can be used to study glutamatergic neuronal transmission with exceptional spatial-temporal resolution in complex tissue preparations.
Production process of hymexazol technical material
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Paragraph 0017-0024, (2017/04/28)
The invention provides a production process of hymexazol technical material. The production process comprises the following steps: hydroxylamine hydrochloride addition, catalyst addition, ethyl acetoacetate dropwise addition, reaction and acidification. The production process of hymexazol technical has the beneficial effects that the selectivity of the catalyst is 99.7-99.9%; the purity of the prepared crude product hymexazol is 91-92%; the yield of the hymexazol technical is 94-95%; the purity of the hymexazol technical material through liquid chromatography detection is 99.98-99.99%. According to the production process of the hymexazol technical material, disclosed by the invention, the catalyst is durable to recycle, and when the catalyst is recycled for 30 times, the purity of the prepared crude product hymexazol is 89.7-90%; the selectivity of the catalyst is 98.5%; the yield of the hymexazol technical is 92-92.4%; the purity of the hymexazol technical material through liquid chromatography detection is more than 99.90%.
