100047-42-5Relevant articles and documents
A new method for the chemical synthesis of the Wee1 protein kinase inhibitor adavosertib
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Paragraph 0045; 0048-0054, (2022/01/12)
The present invention relates to a New Method for the Chemical Synthesis of a Weather1 protein kinase inhibitor adavosertib. The method of the present invention, using an intermediate compound that is commercially readily available, which undergoes a micr
MERTK DEGRADERS AND USES THEREOF
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, (2020/01/31)
The present invention provides compounds, compositions thereof, and methods of using the same.
PHENOXYMETHYL DERIVATIVES
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, (2017/03/21)
The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
ALKYNYL ALCOHOLS AND METHODS OF USE
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Page/Page column 381; 382, (2015/03/13)
The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.
Microwave-assisted, divergent solution-phase synthesis of 1,3,6-trisubstituted pyrazolo[3,4- d ]pyrimidines
Liu, Jing,Wang, Xiaodong
scheme or table, p. 414 - 420 (2011/08/22)
A concise and highly divergent synthetic route has been developed to rapidly access 1,3,6-trisubstituted pyrazolopyrimidines. The synthesis features a microwave assisted one-pot N1-alkylation/Suzuki-Miyaura reaction as the key step. The sequence of the synthetic scheme can be varied to selectively modify the N1, C3, or C6 position at a late synthetic stage, thereby providing a highly efficient approach to explore the structure-activity relationships of pyrazolopyrimidine derivatives. The scope of these reactions has also been explored.