1003-61-8

Basic information

• Product Name: 2-Amino-5-formylthiazole
• Synonyms: 2-AMINOTHIAZOLE-5-CARBALDEHYDE;2-AMINOTHIAZOLE-5-CARBOXALDEHYDE;2-AMINO-5-FORMYLTHIAZOLE;2-Amino-5-formyl-1,3-thiazole;2-Aminothiazole-5-carbadehyde;2-Amino-1,3-thiazole-5-carboxaldehyde 96%;2-AMINOTHIAZOLE-5-CARBALDEHYDE, 98+%;2-AMINOTHIAZOLE-5-CARBALDEHYDE 95%
• CAS NO: 1003-61-8
• Molecular Formula: C₄H₄N₂OS
• Molecular Weight: 128.15
• Product Categories: Aldehydes;Amines;blocks;Thiazoles;Sulphur Derivatives;Thiazoles, Isothiazoles &Benzothiazoles;Thiazole;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks
• Mol File: 1003-61-8.mol

Chemical Properties

• Melting Point: 122-132 °C
• Boiling Point: 316.3 °C at 760 mmHg
• Flash Point: 145.1 °C
• Appearance: /
• Density: 1.488 g/cm³
• Vapor Pressure: 0.000413mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: Keep Cold
• PKA: 3.16±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Amino-5-formylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-formylthiazole(1003-61-8)
• EPA Substance Registry System: 2-Amino-5-formylthiazole(1003-61-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1003-61-8(Hazardous Substances Data)

Usage

Uses

Used in Dye Industry:
2-Amino-5-formylthiazole is used as a reagent for the preparation of cationic azo dyes. The presence of different functional groups in its structure allows for differential attachment of an azo linkage and benzoxazolium salt, which are essential for the formation of cationic, delocalized azo dyes.
Used in Chemical Synthesis:
2-Amino-5-formylthiazole is also used as a building block in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable intermediate for the development of new molecules with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C4H4N2OS/c5-4-6-1-3(2-7)8-4/h1-2H,(H2,5,6)

Upstream product

• 2065-75-0 2-Bromo-malonaldehyde 
• 17356-08-0 thiourea 
• 32284-60-9 N,N-bis(trimethylsilyl)-2-aminothiazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 252662-37-6 N-(5-formyl-1,3-thiazol-2-yl)acetamide 
• 131184-73-1 (2-amino-1,3-thiazol-5-yl)methanol 
• 1001419-48-2 C₁₉H₂₂N₂O₄S₂ 
• 391668-77-2 tert-butyl (5-formylthiazol-2-yl)carbamate 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 859523-71-0 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea 
• 936845-85-1 4-[6-(5-formyl-thiazol-2-ylamino)-2-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1228304-57-1 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-2-carbaldehyde 
• 1005-28-3 2-(dimethylamino)thiazole-5-carbaldehyde 
• 1253116-34-5 C₁₁H₁₅N₃O₂S 
• 924668-30-4 C₁₂H₇F₄N₃O₂S 
• 936845-87-3 4-[4-(5-formyl-thiazol-2-ylamino)-benzenesulfonyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 320423-50-5 2-(4-methylpiperazin-1-yl)thiazole-5-carboxaldehyde 

Relevant articles and documents

Thiazole-diamides as potent γ-secretase inhibitors

The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of 3H]-2a, are d

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis

Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed

H2-antagonists: Synthesis and activity of 2-Amino-5-thiazolyl derivatives

2-Amino- and 2-guanidinothiazole derivatives having in position 5 a methylthioalkyl side-chain with urea-equivalent moieties were prepared for comparison with H2-antagonists of cimetidine and tiotidine series. Examination of the pharmacological results obtained from experiments on guinea pig atria and in cat gastric fistula, suggests some general observations about the structure-activity relationship of the compounds synthesized. The activity trend of these products is different from that of H2-imidazole antagonists while it is similar to that of the tiotidine series. Unlike the tiotidine similar compounds, the 2-guanidino-5-thiazolyl derivatives are less potent than the corresponding 2-amino-5-thiazolyl products. The activity of the latter ones is reduced in comparison to that of tiotidine or cimetidine.

Process for preparing 2-amino-5-formylthiazole and its hydrobromide salt

Process for the preparation of 5-formyl-2-aminothiazole hydrobromide and 2-amino-5-formylthiazole which comprises reacting bromomalonaldehyde and thiourea in the substantial absence of acid or base to form the 5-formyl-2-aminothiazole hydrobromide, and then treating the same with base to form the aminothiazole.