1005-28-3

Usage

Uses

Used in Organic Synthesis:
2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE is used as a reagent for the synthesis of various heterocyclic compounds, contributing to the creation of complex organic molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE serves as a building block in the development of new drugs, facilitating the design and synthesis of novel pharmaceutical agents.
Used in Agricultural Chemicals:
2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE is also utilized in the synthesis of agricultural chemicals, playing a role in the development of new pesticides or other agrochemicals to improve crop protection and yield.
Used as a Fluorescent Probe in Biological Research:
2-DIMETHYLAMINO-THIAZOLE-5-CARBALDEHYDE has shown promise as a fluorescent probe for detecting metal ions in biological systems, which is crucial for understanding metal ion interactions and their roles in biological processes.

InChI:InChI=1/C6H8N2OS/c1-8(2)6-7-3-5(4-9)10-6/h3-4H,1-2H3

Upstream product

• 6142-08-1 2-dimethylamino-1,3-thiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 3034-52-4 2-chlorothiazole 
• 1003-61-8 2-aminothiazole-5-carbaldehyde 
• 74-88-4 methyl iodide 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 124-40-3 dimethyl amine 
• 95453-58-0 2-chloro-1,3-thiazole-5-carbaldehyde 

Relevant academic research and scientific papers

3-thiazolenyl boron fluoride complexed dipyrromethene compound as well as preparation method and application thereof

The invention relates to a 3-thiazolenyl boron fluoride complexed dipyrromethene compound as shown in a general formula I, and a preparation method and application thereof. Experiments prove that theboron fluoride complexed dipyrromethene compound disclos

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

The present invention relates to compounds of the formula (I), wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to thei

Dehydroamino acids

Compounds of formula 1 and 1-1, wherein R1 is hydrogen, hydroxy, amino or halogen, R2 is hydrogen, hydroxy, or halogen and R3 is hydrogen (Formula 1) or R1 is hydrogen and R2 and R3 taken together with the ethenylene group connecting them form phenyl, pyrrole, pyrroline, oxopyrroline, pyrazole, triazole, or imidazole (Formula 1-1), A is R4 R5 are hydrogen, methyl, ethyl or halogen except that R4 r5 cannot both be hydrogen; and 1) B is hydrogen, or lower alkyl; or 2) B is where R6 R7 R8 and R9 are independently hydrogen, hydroxy, aminosulfonyl, halogen, lower alkoxy, cyano, amino, lower alkyl, lower alkyl amino, or nitro; or 3) B is where R10 is hydrogen, hydroxy, halogen, or lower alkyl and C is a five- or six- membered ring with 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur, which ring may be unsubstituted or mono- or di- substituted with lower alkyl, cycloalkyl, amino, or substituted amino; 4) B is where X and Y are independently methylene or nitrogen; or 5) B is where at leat one of T, U, V, or W is nitrogen, and any of T, U, V or W which is carbon may be substituted with lower alkyl, lower alkyl amino, lower alkoxy, hydroxy, aminosulfonyl, halogen, cyano, amino, or nitro; or 6) B is where Y is carbon or nitrogen; or 7) B is a five-membered aromatic ring with 1 to 3 heteratoms selected from nitrogen, oxygen, and sulfur which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalky, trifluoroloweralkyl, amino, halogen, substituted amino, or which ring may be fused with a 5 or 6 membered aromatic ring containing 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur; and pharmaceutically acceptable salts thereof, and related prodrugs, pharmaceutical compositions and methods of treatment, which compounds are useful for treating psoriasis.

An Easy General Synthesis of 2-(N,N-Dialkylamino)thiazol-5-yl Aldehydes and Ketones

Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water.Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.

N,N-Disubstituted 2-Aminothiazole-5-carbaldehydes: Preparation and Investigation of Structural Features

Methods of preparing N,N-disubstituted 2-aminothiazoles have been investigated. 4-Substituted N,N-dimethyl-, N-benzyl-N-methyl-, and N-methyl-N-phenyl-amines were prepared and converted by Vilsmeier formylation into 2-amino-5-carbaldehydes which were examined by i.r. and 1H n.m.r. spectrometry.The aldehyde group adopts the carbonyl O,S-syn-conformation.With the N,N-dimethyl and N-benzyl-N-methyl compounds the barrier to rotation of the amine group (ΔG(excit.)) is 50-55 kJ mol-1 and is insensitive to the nature of the 4-substituent.The amine group of the N-methyl-N-phenyl compounds has a marked preference for one orientation.This was shown by a crystallographic study of 4-t-butyl-2-(N-methyl-N-phenylamino)thiazole-5-carbaldehyde to have the phenyl group directed towards the sulphur atom of the thiazole ring.