1003-73-2Relevant articles and documents
Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines
Leroy,Despres,Bigan,Blondeau
, p. 2257 - 2272 (1996)
Dioxaphosphorino[m,n-x]pyridines compounds have been prepared by condensation of methyl dichlorophosphate with new ortho-hydroxymethylpyridinols.
Silica-supported vanadium-catalyzed N-oxidation of tertiary amines with aqueous hydrogen peroxide
Rout, Laxmidhar,Punniyamurthy, Tharmalingam
, p. 1958 - 1960 (2005)
A recyclable silica supported vanadium 1 catalyzes the oxidation of tertiray amines to the corresponding N-oxides with 30% H2O 2 in high yield.
A comparison of methods for N-oxidation of some 3-substituted pyridines
Bremner, David H.,Sturrock, Keith R.,Wishart, Grant,Mitchell, Stewart R.,Nicoll, Stuart M.,Jones, Gareth
, p. 1535 - 1542 (1997)
The results from the N-oxidation of four 3-substituted pyridines using five different reagents are reported. The best yields are obtained with m-chloroperoxybenzoic acid.
Raman spectra of 3-methyl-4-nitropyridine-N-oxide single crystal
Zhang, Delong,Lan, Guoxiang,Hu, Shifen,Wang, Huafu,Zheng, Jimin
, p. 1065 - 1072 (1994)
A Raman study of 3-methyl-4-nitropyridine-N-oxide single crystal (3M4NPO) has been performed at 78 K in the range 10-3500 cm-1.The symmetry analysis of the vibrational modes of 3M4NPO is given.The assignments are presented for internal and external modes.The results of the Raman spectra exhibit the spectroscopic proofs of hydrogen bonds in the crystal.
Metal-Free, Phosphonium Salt-Mediated Sulfoximination of Azine N-Oxides: Approach for the Synthesis of N-Azine Sulfoximines
Aithagani, Sravan Kumar,Kumar, Mukesh,Yadav, Mahipal,Vishwakarma, Ram A.,Singh, Parvinder Pal
, p. 5886 - 5894 (2016)
Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2′-bipyridine, 1,10-phenanthroline, and quinine.
Visible-Light-Induced Decarboxylative Acylation of Pyridine N-Oxides with α-Oxocarboxylic Acids Using Fluorescein Dimethylammonium as a Photocatalyst
Hou, Chuanfu,Sun, Shouneng,Liu, Ziqi,Zhang, Hui,Liu, Yue,An, Qi,Zhao, Jian,Ma, Junjie,Sun, Zhizhong,Chu, Wenyi
supporting information, p. 2806 - 2812 (2021/04/15)
Herein, the development of a visible-light-induced catalytic system to achieve the decarboxylative acylation of pyridine N-oxides with α-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst, is reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium has been used to catalyze the Minisci-type C?H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene to confirm a radical mechanism. The disclosed catalytic system provides a green synthetic strategy for decarboxylative acylation without the use of additional oxidants or metal catalysts. (Figure presented.).
Strategic Approach on N-Oxides in Gold Catalysis – A Case Study
Schie?l, Jasmin,Stein, Philipp M.,Stirn, Judith,Emler, Kirsten,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
supporting information, p. 725 - 738 (2018/10/20)
An extensive kinetic study of selected key reactions of (oxidative) gold catalysis concentrates on the decrease of the catalytic activity due to inhibition of the gold(I) catalyst caused by pyridine derivatives that are obtained as by-products if N-oxides are applied as oxygen donors. The choice of the examined pyridine derivatives and their corresponding N-oxides has been made regardless of their commercial availability; particular attention has been paid to the practical benefit which up to now has been neglected in most of the reaction screenings. The test reactions were monitored by GC and 1H NMR spectroscopy. The received reaction constants provide information concerning a correlation between the electronic structure of the heterocycle and the catalytic activity. Based on the collected kinetic data, it was possible to develop a basic set of three N-oxides which have to be taken into account in further oxidative gold(I)-catalyzed reactions. (Figure presented.).
