100724-16-1

Basic information

• Product Name: ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE
• Synonyms: ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE;4-Phenyl-5-pyrimidinecarboxylic acid ethyl ester
• CAS NO: 100724-16-1
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Mol File: 100724-16-1.mol

Chemical Properties

• Melting Point: 159-161℃
• Boiling Point: 393.2°Cat760mmHg
• Flash Point: 191.6°C
• Appearance: /
• Density: 1.167
• Vapor Pressure: 2.17E-06mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE(100724-16-1)
• EPA Substance Registry System: ETHYL-4-PHENYL PYRIMIDINE-5-CARBOXYLATE(100724-16-1)

Safety Data

• Hazardous Substances Data: 100724-16-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2O2/c1-2-17-13(16)11-8-14-9-15-12(11)10-6-4-3-5-7-10/h3-9H,2H2,1H3

Upstream product

• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 
• 122-51-0 orthoformic acid triethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 77287-34-4 formamide 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 6313-33-3 formamidine hydrochloride 

Downstream Products

• 92084-99-6 4-phenyl-pyrimidine-5-carboxylic acid 

Relevant articles and documents

Oxidative Annulations Involving DMSO and Formamide: K2S2O8 Mediated Syntheses of Quinolines and Pyrimidines

An efficient strategy toward 4-arylquinolines and 4-arylpyrimidines from readily available precursors is described. Oxidative annulation promoted by K2S2O8 involving anilines, aryl ketones, and DMSO as a methine (=CH-) equivalent leads to 4-arylquinolines via a cascade that entails generation of a sulfenium ion, subsequent C-N and C-C bond formations, and cyclization. The application of this strategy to the activation of acetophenone-formamide conjugates toward the synthesis of 4-arylpyrimidines is also described.

PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceut

An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction

We have developed a ZnCI2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.