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4,6-Dichloro-2-phenylquinoline, a quinoline derivative with the molecular formula C15H9Cl2N, is an organic compound belonging to the chloroquinolines class. It is recognized for its potential therapeutic properties in medicinal chemistry and pharmacology.

100914-76-9

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100914-76-9 Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dichloro-2-phenylquinoline is used as an antibacterial and antifungal agent for its demonstrated activities against various infectious diseases, making it a valuable compound in the development of new treatments for bacterial and fungal infections.
Used in Anticancer Applications:
In the field of oncology, 4,6-Dichloro-2-phenylquinoline is used as a potential anticancer agent due to its inhibitory effects on cancer cell growth. It is being studied for its ability to target and reduce the proliferation of cancer cells, offering a promising avenue for cancer treatment development.
Used in Medicinal Chemistry Research:
4,6-Dichloro-2-phenylquinoline serves as a key compound in medicinal chemistry research, where it is investigated for its structure-activity relationships and potential modifications to enhance its therapeutic effects, thereby contributing to the discovery of novel drugs with improved efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 100914-76-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,1 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 100914-76:
(8*1)+(7*0)+(6*0)+(5*9)+(4*1)+(3*4)+(2*7)+(1*6)=89
89 % 10 = 9
So 100914-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H9Cl2N/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9H

100914-76-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-DICHLORO-2-PHENYLQUINOLINE

1.2 Other means of identification

Product number -
Other names 4,6-dichloro-2-phenyl-quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100914-76-9 SDS

100914-76-9Downstream Products

100914-76-9Relevant articles and documents

ANTIMALARIAL COMPOUNDS

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Page/Page column 42-43, (2020/10/20)

Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines

Huang, Guang,Murillo Solano, Claribel,Melendez, Joel,Shaw, Justin,Collins, Jennifer,Banks, Robert,Arshadi, Arash Keshavarzi,Boonhok, Rachasak,Min, Hui,Miao, Jun,Chakrabarti, Debopam,Yuan, Yu

, p. 11756 - 11785 (2020/11/26)

There is an urgent need to develop new efficacious antimalarials to address the emerging drug-resistant clinical cases. Our previous phenotypic screening identified styrylquinoline UCF501 as a promising antimalarial compound. To optimize UCF501, we herein report a detailed structure-activity relationship study of 2-arylvinylquinolines, leading to the discovery of potent, low nanomolar antiplasmodial compounds against a Plasmodium falciparum CQ-resistant Dd2 strain, with excellent selectivity profiles (resistance index 200). Several metabolically stable 2-arylvinylquinolines are identified as fast-acting agents that kill asexual blood-stage parasites at the trophozoite phase, and the most promising compound 24 also demonstrates transmission blocking potential. Additionally, the monophosphate salt of 24 exhibits excellent in vivo antimalarial efficacy in the murine model without noticeable toxicity. Thus, the 2-arylvinylquinolines represent a promising class of antimalarial drug leads.

Quinoline derivatives as antitubercular/antibacterial agents

Desai,Desai, Pratibha,Machhi, Dilip,Desai,Patel, Dinesh

, p. 871 - 873 (2007/10/03)

A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.

4-Piperidino-2-phenylquinolines

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, (2008/06/13)

Disclosed are compounds of the formula STR1 wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.

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