102113-98-4

Basic information

• Product Name: Bis(4-biphenylyl)amine
• Synonyms: 4,4'-IMINOBIS(BIPHENYL);BIS(4-BIPHENYLYL)AMINE;BIS-BIPHENYL-4-YL-AMINE ;Bis(4-biphenyl)amine;Bis(1,1'-biphenyl-4-yl)amine Di(biphenyl-4-yl)amine;4,4'-IMINOBIS(BIPHEN;Di(biphenyl-4-yl)amine;N-[1,1'-biphenyl]-4-yl-[1,1'-biphenyl]-4-Mine
• CAS NO: 102113-98-4
• Molecular Formula: C₂₄H₁₉N
• Molecular Weight: 321.41
• EINECS: 1312995-182-4
• Product Categories: OLED materials,pharm chemical,electronic
• Mol File: 102113-98-4.mol
• Article Data: 120

Chemical Properties

• Melting Point: 209 °C
• Boiling Point: 507 °C at 760 mmHg
• Flash Point: 281.7 °C
• Appearance: /
• Density: 1.123 g/cm³
• Vapor Pressure: 0-0Pa at 20-50℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
• PKA: 0.67±0.40(Predicted)
• CAS DataBase Reference: Bis(4-biphenylyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(4-biphenylyl)amine(102113-98-4)
• EPA Substance Registry System: Bis(4-biphenylyl)amine(102113-98-4)

Safety Data

• Hazardous Substances Data: 102113-98-4(Hazardous Substances Data)

Usage

Uses

Bis(4-biphenylyl)amine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process and chemical production process.

Synthesis

Bis(4-bromophenyl)amine (4.0 g, 12.3 mmol) and phenylboronic acid (4.0 g, 32.7 mmol) were mixed in 250 mL of toluene and 60 mL of ethanol. The solution was bubbled with nitrogen while stirring for 15 minutes. Pd(PPh3)4 (1.4 g, 1.23 mmol) and K3PO4 (13.5 g, 64 mmol) were added in sequence. The mixture was heated to reflux overnight under nitrogen. After cooling, the reaction mixture was filtered through filter paper and the solvent was then evaporated. The solid was redissolved in nitrogen-purged hot toluene and was filtered through a Celite?/silica pad when the solution was still hot. The solvent was then evaporated. The white crystalline solid was washed by hexane and air dried to obtain 3.8 g of Bis(4-biphenylyl)amine.

Upstream product

• 1591-31-7 4-iodo-biphenyl 
• 4075-79-0 4-phenylacetanilide 
• 92-67-1 4-phenylalanine 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 16292-17-4 bis(4-bromophenyl)amine 
• 98-80-6 phenylboronic acid 
• 109-99-9 tetrahydrofuran 
• 1493-13-6 trifluorormethanesulfonic acid 
• 2051-62-9 4'-biphenyl chloride 
• 122-39-4 diphenylamine 
• 741267-16-3 N,N-di([1,1'-biphenyl]-4-yl)benzamide 
• 462631-32-9 N,N-di-(4-biphenyl)benzylamine 
• 7440-05-3 palladium 
• 59501-33-6 bis-biphenyl-4-yl-nitroso-amine 

Downstream Products

• 122215-84-3 N-([1,1'-biphenyl]-4-yl)-N-phenyl-[1,1'-biphenyl]-4-amine 
• 6543-20-0 tris(p-biphenyl)amine 
• 1085434-47-4 C₆₄H₄₆N₂ 
• 1085434-55-4 C₇₀H₅₀N₂ 
• 1240964-23-1 C₆₀H₄₀N₂O 
• 1421701-43-0 N,N-bis({[1,1'-biphenyl]-4-yl})-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-4-amine 
• 1421701-44-1 C₆₀H₄₀N₂ 
• 1421701-39-4 C₅₄H₃₆N₂ 
• 728039-63-2 N,N-di([1,1′-biphenyl]-4-yl)-4′-bromo-[1,1′-biphenyl]-4-amine 
• 1346506-17-9 N,N-di(biphenyl-4-yl)-10-ethyl-10H-phenanthro[9,10-b]carbazol-3-amine 
• 1427738-35-9 C₅₄H₃₆N₂S 
• 1351866-85-7 C₆₀H₄₀N₂ 

Relevant articles and documents

Probing the Influence of PAd-DalPhos Ancillary Ligand Structure on Nickel-Catalyzed Ammonia Cross-Coupling

We report herein on the results of our combined experimental/computational study regarding the catalytic performance of PAd-DalPhos (L1) in nickel-catalyzed ammonia arylation for primary aniline synthesis. Primary arylamine C-N reductive eliminations occurring from arylnickel(II) parent amido complexes of the type (L)Ni(Ph)(NH2) were modeled by use of density-functional theory (DFT) methods, for a series of L1 derivatives. The dual aims were to assess the effect of structural modifications to L1 on potentially rate-limiting C-N reductive elimination and to identify promising candidates for experimental inquiry. Increasing the steric demand of the Paryl groups from o-tolyl (in L1) to mesityl (in L16) resulted in a significant lowering of the barrier to C-N reductive elimination (ΔG?RE), which can be attributed in part to interactions between the ligand Paryl groups and the nickel-bound amido ligand, as observed in noncovalent interaction (NCI) plots of the reductive elimination transition-state structures. Despite the favorability of L16 predicted on the basis of computational analysis focusing on C-N reductive elimination, this ancillary ligand performed poorly in experimental testing versus L1, suggesting that in practice the significant steric demands of L16 may discourage the formation of key catalytic intermediates. Modifications to the steric profile of the Paryl groups in L1 led to dramatic changes in catalytic performance, with the presence of an o-methyl proving to be important, among the L1 variants tested, in achieving useful catalytic performance in the Ni-catalyzed monoarylation of ammonia.

DMSO-allyl bromide: A mild and efficient reagent for atom economic one-pot: N -allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles

A mixture DMSO-allyl bromide has been developed as a reagent for an atom economic one-pot N-allylation and aryl bromination under basic conditions. Utilizing this reagent, N-allylation-bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed.

CH Activation of Cationic Bismuth Amides: Heteroaromaticity, Derivatization, and Lewis Acidity

Cationization of Bi(NPh2)3 has recently been reported to allow access to single- and double-CH activation reactions, followed by selective transformation of Bi–C into C–X functional groups (X = electrophile). Here we show that this approach can successfully be transferred to a range of bismuth amides with two aryl groups at the nitrogen, Bi(NRaryl2)3. Exchange of one nitrogen-bound aryl group for an alkyl substituent gave the first example of a homoleptic bismuth amide with a mixed aryl/alkyl substitution pattern at the nitrogen, Bi(NPhiPr)3. This compound is susceptible to selective N–N radical coupling in its neutral form and also undergoes selective CH activation when transformed into a cationic species. The second CH activation is blocked due to the absence of a second aryl moiety at nitrogen. The Lewis acidity of neutral bismuth amides is compared with that of cationic species “[Bi(aryl)(amide)(L)n]+” and “[Bi(aryl)2(L)n]+” based on the (modified) Gutmann–Beckett method (L = tetrahydrofuran or pyridine). The heteroaromatic character of [Bi(C6H3R)2NH(triflate)] compounds, which are iso-valence-electronic with anthracene, is investigated by theoretical methods. Analytical methods used in this work include nuclear magnetic resonance spectroscopy, single-crystal X-ray diffraction, mass spectrometry, and density functional theory calculations.