103419-18-7

Basic information

• Product Name: (-)-(S)-Cibenzoline
• Synonyms: (-)-(S)-Cibenzoline;1H-Imidazole, 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-, (S)-;1H-Imidazole, 2-[(1S)-2,2-diphenylcyclopropyl]-4,5-dihydro-
• CAS NO: 103419-18-7
• Molecular Formula: C18H18 N2
• Molecular Weight: 0
• Mol File: 103419-18-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-(S)-Cibenzoline(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(S)-Cibenzoline(103419-18-7)
• EPA Substance Registry System: (-)-(S)-Cibenzoline(103419-18-7)

Safety Data

• Hazardous Substances Data: 103419-18-7(Hazardous Substances Data)

Usage

General Description

(-)-(S)-Cibenzoline is a chemical compound that belongs to the class of benzodiazepines. It is a chiral molecule with the (S)-enantiomer being the active form. This chemical is used as an antiarrhythmic agent, specifically for the treatment of severe ventricular arrhythmias. It works by slowing down the heart rate and stabilizing the heart's rhythm, making it an effective medication for managing irregular heartbeats and preventing potentially life-threatening arrhythmias. (-)-(S)-Cibenzoline is typically administered orally and has been found to be well-tolerated with minimal side effects, making it a valuable option for individuals with serious heart rhythm disturbances.

Upstream product

• 107-15-3 ethylenediamine 
• 926905-41-1 2,2-diphenylcyclopropane-1-carbaldehyde 
• 109546-07-8 N-(2-aminoethyl)-2,2-diphenylcyclopropanecarboxamine 
• 57625-97-5 Cibenzoline succinate 
• 53267-01-9 cifenline 
• 926905-44-4 N-(2-aminoethyl)-2,2-diphenylcyclopropane-carboxamide 
• 28098-84-2 1-cyano-2,2-diphenylcyclopropane 
• 149030-24-0 (1R)-1,1-diphenyl-2-hydroxymethylcyclopropane 
• 53692-74-3 (R)-2,2-diphenylcyclopropanecarboxylic acid 
• 4801-14-3 3,3-diphenylprop-2-en-1-ol 

Downstream Products

• 57625-97-5 R-(+)-cibenzoline succinate 
• 103419-18-7 [14C]-(+)-Cibenzoline 
• 57625-97-5 S-(-)-cibenzoline succinate 
• 103419-18-7 [14C]-(-)-Cibenzoline 

Relevant articles and documents

Novel Process For The Preparation Of (-)-Cibenzoline Succinate

The present invention relates to a crystalline form of (-)-cibenzoline succinate. The present invention also relates to a method for manufacturing (-)-cibenzoline succinate having a chiral purity of 99.9% or higher. In addition, the present invention provides the method for manufacturing (-)-cibenzoline succinate and a crystalline form thereof. The (-)-cibenzoline succinate according to the present invention is economical and remarkably advantageous for mass production.COPYRIGHT KIPO 2020

Convenient preparation of optically active cibenzoline and analogues from 3,3-diaryl-2-propen-1-ols

(R)-(+)-Cibenzoline (95% ee) was synthesized in two steps from (+)-2,2-diphenylcyclopropylmethanol 3a (98% ee), which was oxidized with IBX in DMSO, followed by treatment with ethylenediamine in the presence of I2 and K2CO3/sub

Syntheses of (R)-(+)-cibenzoline and analogues via catalytic enantioselective cyclopropanation using (S)-phenylalanine-derived disulfonamide

Cyclopropanation of 3,3-diaryl-2-propen-1-ols 1 with Et2Zn and CH2I2 proceeded in the presence of a catalytic amount of (S)-2-(methanesulfonyl)amino-1-(p-toluenesulfonyl)amino-3-phenylpropane 2 to afford the corresponding