10538-49-5Relevant articles and documents
Chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of CuPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as highly efficient catalyst
Bayrak, Cetin,Menzek, Abdullah,Sevim, Melike
, (2021/12/09)
Herein, we reported reductions of acid, amide, ester and ketone groups with selectivity (>99%) by the catalytic transfer hydrogenation of with CuPd alloy nanoparticles (NPs) decorated on mesoporous graphitic carbon nitride (Cu50Pd50/mpg-C3N4) catalyst under mild conditions in a water/methanol mixture. CuPd alloy NPs were synthesized by the co-reduction of palladium (II) acetylacetonate and copper(II) acetylacetonate in oleylamine (OAm) solution by the reduction of morpholine-borane solution and then assembled on mpg-C3N4 via liquid phase self‐assembly method. The α, β-unsaturated carbonyl compounds were obtained from the condensation reaction of the benzaldehyde derivatives with acetone derivatives. Cu50Pd50/mpg-C3N4 nanocatalyst was characterized by TEM, XRD, XPS, BET and ICP‐MS. Cu50Pd50/mpg-C3N4 nanocatalyst is highly active catalyst for the reduction of various organic groups and converted to high yield and 99% selectivity. The superior Cu50Pd50/mpg-C3N4 nanocatalyst is highly efficient and reusable catalyst which is reuse after 5 cycle with 98% conversion.
Sesquiterpene lactone-cinnamic acid derivative and salt, pharmaceutical composition and application thereof
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Paragraph 0118-0119, (2020/08/09)
The invention provides application of sesquiterpene lactone-cinnamic acid derivatives shown as a formula (I) and salts thereof in preparation of medicines for treating cancers and auxiliary medicinesfor treating cancers.
Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents
Ge, Weizhi,Hao, Xin,Han, Fangzhi,Liu, Zhongquan,Wang, Tianpeng,Wang, Mengmeng,Chen, Ning,Ding, Yahui,Chen, Yue,Zhang, Quan
, p. 445 - 469 (2019/02/12)
Triple-negative breast cancer (TNBC) is the most aggressive cancers with a high recurrence rate and rapidly acquired drug resistance among various breast cancer subtypes. There is no specific drug for treatment of TNBC. Discovery of therapeutic agents with unique modes of actions is urgently needed. In this study, a series of seventy parthenolide derivatives was designed, synthesized, and evaluated for their anti-TNBC activities. Compound 7d exhibited the most potent activity against different breast cancer cells with IC50 values ranging from 0.20 μM to 0.27 μM, which demonstrated 11.6- to 18.6-fold improvement comparing to that of the parent compound parthenolide with IC50 values of 2.68–4.63 μM. It is worth to note that 7d was more active than the positive control drug ADR. Moreover, compound 7d could induce apoptosis of SUM-159 cells through mitochondria pathway and cause G1 phase arrest of SUM-159 cells. These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug.
Synthesis and rearrangement of cage [4.3.2]propellanes that contain a spiro linkage
Kotha, Sambasivarao,Cheekatla, Subba Rao,Mandal, Binita
, p. 4277 - 4282 (2018/08/28)
Rearranged cage ketones 6a and 6b are reported in eight linear synthetic steps from 2,5-dimethoxybenzaldehyde 9 without the use of protecting groups. In this regard, Diels–Alder reaction, [2+2]photocycloaddition and Lewis acid promoted rearrangement with BF3·OEt2 were used as key steps. Surprisingly, during the ring expansion process with Lewis acid, solvent in-corporation occurred. This rearrangement approach has provided difficult complex targets through non-obvious synthetic routes. The rearrangement process demonstrated here opens up a new synthetic strategy to interesting and unusual cage molecules.
SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
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Page/Page column 0260, (2015/11/09)
Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.
SPIRO RING COMPOUND AS HEPATITIS C VIRUS (HCV) INHIBITOR AND USES THEREOF FIELD OF THE INVENTION
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Page/Page column 139; 140, (2014/06/23)
A compound of formula (I) or a stereoisomer, a geometric isomer. a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder.
Synthesis and characterization of geminally dialkylsubstituted tetraindanotetraoxa[8]circulenes
Mejlsoe, Soren L.,Christensen, Jorn B.
, p. 1051 - 1057 (2014/08/05)
A synthetic methodology for the synthesis of 2,2-dialkyl-4,7-dimethoxy-2,3- dihydro-1H-inden-1-ones from 4,7-dimethoxy-2,3-dihydro-1H-inden-1-one has been developed, and some of these compounds were converted into the corresponding geminally dialkylsubstituted tetraindanotetraoxa[8]circulenes with the expectation of obtaining discotic liquid crystalline materials.
SYNTHESIS OF RIGIDLY LINKED TRIAD MOLECULES BASED ON OCTAALKYLPORPHYRIN, CAPABLE OF MULTISTEP ELECTRON TRANSFER
Gribkov, A.A.,Borovkov, V.V.,Evstigneeva, R.P.,Sakata, Y.
, p. 905 - 915 (2007/10/02)
We have designed and carried out the synthesis of triad model systems containing octaalkylporphyrin, benzoquinone, and trichlorobenzoquinone with an oxidation-reduction potential gradient in the molecule.The quinone moieties are fixed relative to the porphyrin using spirononane and methylene spacers.
