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N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is a chemical compound characterized by the presence of a benzoyl group, a dimethoxytrityl group, and an O-methyladenosine group. It is widely recognized for its role in the synthesis of RNA molecules and nucleoside analogs, acting as a crucial building block in the creation of modified nucleosides for research. N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is particularly noted for its capacity to improve the stability and binding specificity of RNA molecules, which makes it an indispensable tool in the investigation of RNA's structure and function. Furthermore, it holds promise for the development of innovative RNA-based therapeutics and drug delivery systems.

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  • N-(9-((2R,3R,4R,5R)-5-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-HYDROXY-3-METHOXYTETRAHYDROFURAN-2-YL)-9H-PURIN-6-YL)BENZAMIDE

    Cas No: 110764-72-2

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  • 110764-72-2 Structure
  • Basic information

    1. Product Name: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
    2. Synonyms: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE;DMT-2'-OMe-Bz-A;N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine;Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-adenosine;N-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-4-hydroxy-3-Methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzaMide;DMTr-2'-OMe-ABz;5'-DMT-2'-OMe-Bz-A
    3. CAS NO:110764-72-2
    4. Molecular Formula: C39H37N5O7
    5. Molecular Weight: 687.74038
    6. EINECS: 2017-001-1
    7. Product Categories: N/A
    8. Mol File: 110764-72-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: White to Pale Yellow/Powder
    5. Density: 1.32±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: Soluble in chloroform at 50mg/ml
    9. PKA: 7.87±0.43(Predicted)
    10. CAS DataBase Reference: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(110764-72-2)
    12. EPA Substance Registry System: N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE(110764-72-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 110764-72-2(Hazardous Substances Data)

110764-72-2 Usage

Uses

Used in Chemical Synthesis:
N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is used as a key building block for the synthesis of RNA molecules and nucleoside analogs, facilitating the production of modified nucleosides that are vital for research purposes.
Used in Research Applications:
In the field of research, N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is utilized as a tool to enhance the stability and binding specificity of RNA molecules, thereby aiding in the study of RNA structure and function.
Used in Pharmaceutical Development:
N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is used as a component in the development of novel RNA-based therapeutics, contributing to the advancement of treatments that leverage the unique properties of RNA.
Used in Drug Delivery Systems:
In the pharmaceutical industry, this compound is employed in the design of drug delivery systems, potentially improving the efficacy and targeted delivery of RNA-based drugs.
Used in Biochemistry and Molecular Biology:
N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE is used as a reagent in biochemical and molecular biology applications, supporting experiments that explore the interactions and mechanisms involving RNA molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 110764-72-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,7,6 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 110764-72:
(8*1)+(7*1)+(6*0)+(5*7)+(4*6)+(3*4)+(2*7)+(1*2)=102
102 % 10 = 2
So 110764-72-2 is a valid CAS Registry Number.

110764-72-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE

1.2 Other means of identification

Product number -
Other names DMT-2'-OMe-Bz-A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:110764-72-2 SDS

110764-72-2Relevant articles and documents

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

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Paragraph 0042; 0215, (2021/06/22)

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates

Penjarla, Srishylam,Prasad, S. Rajendra,Reddy, Dhande Sudhakar,Banerjee, Shyamapada,Penta, Santhosh,Sanghvi, Yogesh S.

, p. 232 - 247 (2018/05/14)

Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this methodology was further exemplified via DMTr- and DMPx-protection of alipahtic acyclic and cyclic diols.

TRINUCLEOTIDE MRNA CAP ANALOGS

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Paragraph 0119, (2018/04/26)

What is described is a trinucleotide cap analog comprising m7G(5′)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′)p3 is a 5′,5′-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.

Synthesis of Leishmania cap-4 intermediates, cap-2 and cap-3

Lewdorowicz, Magdalena,Stepinski, Janusz,Kierzek, Ryszard,Jemielity, Jacek,Zuberek, Joanna,Yoffe, Yael,Shapira, Michal,Stolarski, Ryszard,Darzynkiewicz, Edward

, p. 1339 - 1348 (2008/09/18)

Synthesis of Leishmania mRNA 5′-cap analogs, m7Gpppm26AmpAm (cap-2), and m7Gpppm26AmpAmpCm (cap-3) is reported. Binding affinities of those cap analogs for LeishIF4E proteins were determined using fluorescence spectroscopy. Cap-3 showed similar affinity to LeishIF4Es compared to the mature trypanosomatids cap structure (cap-4). Copyright Taylor & Francis Group, LLC.

An efficient multigram synthesis of monomers for the preparation of novel oligonucleotides containing isosteric non-phosphorous backbones

Dimock, Stuart,Bhat, Balkrishen,Peoc'h, Didier,Sanghvi, Yogesh S.,Swayze, Eric E.

, p. 1629 - 1632 (2007/10/03)

The facile preparation of two novel classes of nucleoside analogs for the inclusion as dimeric non-phosphorous containing subunits in chime fie backbones has been accomplished. The concise preparation of 3'- formylnucleosides and 5'-O-(N-methylhydroxylamino)-nucleosides is reported.

Oligo(2′-O-methylribonucleotides) and their derivatives. II. Synthesis and properties of oligo(2′-O-methylribonucleotides) modified with N-(2-hydroxyethyl)phenazinium and steroid groups at the 5′-terminus

Sergeeva,Lokhov,Ven'yaminova

, p. 800 - 806 (2007/10/03)

Oligo(2′-O-methylribonucleotides) modified at the 5′-terminus with a steroid (cholesterol or testosterone) or polycyclic aromatic dye N-(2-hydroxyethyl)phenazinium residue were synthesized. It was shown that the introduction of an N-(2-hydroxyethyl)phenazinium moiety into octa(2′-O-methylribonucleotide) increased the melting temperature of the duplex with the d-target by 9°C. The steroid residue, which was attached to the 5′-position of deca(2′-O-methyluridylate) via a phosphodiester linkage, enhanced the stability of the steroid conjugate complexes with d(pA)16 and (pA)16; this effect was stronger with the cholesterol derivative (ΔTm 5 and 8°C, respectively) than with the testosterone derivative(ΔTm 1 and 4°C).

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