129666-75-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 4546-55-8 N-benzoyladenosine 
• 1348775-39-2 adenosine 
• 98-88-4 benzoyl chloride 
• 4005-49-6 N-benzoyladenine 

Downstream Products

• 129451-68-9 N⁶-benzoyl-5'-O-dimethoxytrityladenosine 2',3'-cyclic phosphoromorpholidite 
• 96026-71-0 4-Oxo-pentanoic acid (2R,3S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-3-yl ester 
• 140210-68-0 6-N-Benzoyl-5'-O-(4,4'-dimethoxy)trityladenosine 2',3'-bis(O-(2-cyanomethyl)-O-ethyl phosphate) 
• 81256-88-4 N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 129681-71-6 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine 
• 110764-72-2 N⁶-benzoyl-5'-(4,4'-dimethoxytrityl)-O^2'-methyladenosine 
• 127212-38-8 N⁶-benzoyl-5'-O-dimethoxytrityl-3'-O-methyl-3'-deoxyadenosine 
• 133465-48-2 C₅₂H₄₃N₅O₉ 
• 312710-15-9 3'-O-acetyl-2'-O{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 
• 312710-06-8 Phosphoric acid (2R,3R,4R,5R)-5-(6-amino-purin-9-yl)-3-hydroxy-4-[(S)-1-(2-nitro-phenyl)-ethoxymethoxy]-tetrahydro-furan-2-ylmethyl ester methyl ester 
• 312710-16-0 3'-O-acetyl-2'-O{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 5'-(2-cyanoethyl methyl phosphate) 
• 312709-99-2 3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 
• 312710-20-6 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 3'-{N-[(benzyloxy)carbonyl]-L-phenylalaninate} 5'-(methyl phosphate) 
• 312710-21-7 2'-O-{[(S)-1-(2-nitrophenyl)ethoxy]methyl}adenosine 5'-(methyl phosphate) 3'-O-{N-{[(2-nitrobenzyl)oxy]carbonyl}-D-phenylalaninate} 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

UNA AMIDITES AND USES THEREOF

Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a disease which utilize a composition or

CYCLIC DINUCLEOTIDES AS AGONISTS OF STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING

Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism

Simplifying access to synthetic nucleosides is of interest due to their widespread use as biochemical or anticancer and antiviral agents. Herein, a direct stereoselective method to access an expansive range of both natural and synthetic nucleosides up to a gram scale, through direct glycosylation of nucleobases with 5-O-tritylribose and other C5-modified ribose derivatives, is discussed in detail. The reaction proceeds through nucleophilic epoxide ring opening of an in situ formed 1,2-anhydrosugar (termed “anhydrose”) under modified Mitsunobu reaction conditions. The scope of the reaction in the synthesis of diverse nucleosides and other 1-substituted riboside derivatives is described. In addition, a mechanistic insight into the formation of this key glycosyl donor intermediate is provided.

Synthesis and biological evaluation of novel selenonucleosides

A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleos

Synthesis and structural characterization of diastereomeric isomers of RNA trimer adenylyl(3′-5′)adenylyl(3′-5′)adenosine

We have synthesized the diastereomeric isomers of adenylyl(3′- 5′)adenylyl(3′-5′)adenosine (ApApA), and investigated their helical structures and hybridization properties with d-poly(U) by circular dichroism (CD) and UV melting experiments. The configurat

New catalists and procedures for the dimethoxytritylation and selective silylation of ribonucleosides

Procedures have been developed for the selective formation of (a) 2',5'-silylated ribonucleosides and (b) 3',5'-silylated ribonucleosides.These procedures also permit the selective silylation at either the 2'- or 3'-position of dimethoxytritylated ribonuc