111373-03-6Relevant articles and documents
Rapid and efficient synthesis of 1-Arylpiperazines under microwave irradiation
Jaisinghani, Harsha G.,Khadilkar, Bhushan M.
, p. 6875 - 6876 (1997)
1-Arylpiperazines, finding wide applicability in pharmaceuticals were synthesized easily under microwave irradiation from bis(2-chloroethyl)amine hydrochloride and substituted anilines without any solvent. The reaction time was just 1-3 mins. 1-Arylpiperazines were synthesized in 53 to 73% yields. Potent serotonin ligands like Trifluoromethylphenylpiperazine (TFMPP) and 3-Chlorophenylpiperazine (mCPP) were also prepared in just 1 min and 2 mins respectively.
Identification of novel GLUT inhibitors
Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig
, p. 1732 - 1737 (2016/07/27)
The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.
Ligand-free Cu-catalyzed cyanation of aryl halides with K 4[Fe(Cn)6] in water
Ren, Yunlai,Zhao, Shuang,Tian, Xinzhe,Liu, Zhifei,Wang, Jianji,Yin, Weiping
scheme or table, p. 564 - 567 (2010/04/23)
A simple methodology for Cu-catalyzed cyanation of aryl halides with K 4[Fe(CN)6] was developed with water as the solvent in conjunction with ligand-free Cu(OAc)2·H2O as the catalyst. The suggested methodology i