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Cas Database

112828-13-4

112828-13-4

Identification

  • Product Name:1H-Indene-1-acetaldehyde, 4-[(2E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-α,7a-dimethyl-, (αS,1R,3aS,4E,7aR)-

  • CAS Number: 112828-13-4

  • EINECS:

  • Molecular Weight:573.02

  • Molecular Formula: C34H60O3Si2

  • HS Code:

  • Mol File:112828-13-4.mol

Synonyms:(1S,3R,5E,7E)-1,3-Bis-[(tert-butyldiMethylsilyl)oxy]-9,10-secopregna-5,7,10-triene-20-carboxaldehyde;(αS,1R,3aS,4E,7aR)-4-[(2E)-[(3S,5R)-3,5-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-α,7a-diMethyl-1H-indene;(S)-2-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldiMethylsilyloxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)propanal

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:(1S,3R,5E,7E)-1,3-Bis-[(tert-butyldimethylsilyl)oxy]-9,10-secopregna-5,7,10-triene-20-carboxaldehyde
  • Packaging:2.5mg
  • Price:$ 210
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Relevant articles and documentsAll total 7 Articles be found

Enantiomeric impurity PY2 of tacalcitol and preparation method and application thereof

-

, (2018/05/30)

The invention discloses an enantiomeric impurity PY2 of tacalcitol, i.e., (1 alpha, 3 beta, 5Z, 7E, 24S)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, and a preparation method thereof, and belongsto the technical field of chemical pharmaceutical. The high-purity relevant impurity PY2 of the tacalcitol, which is disclosed by the invention, can be used as an impurity standard substance in the tacalcitol finished product detection analysis so as to promote accurate positioning and nature determination of the tacalcitol finished product detection analysis on the impurity and benefit reinforcement of control on the impurity, thereby improving quality of a tacalcitol finished product. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, the operation is simple, the reproducibility is good in and the HPLC (High Performance Liquid Chromatography) purity is greater than or equal to 99.5%.

Synthesis of 24(28)-methylene-1α-hydroxyvitamin D3, a novel vitamin D3 analogue

Guo, Wei,Fang, Zhijie,Li, Hongliang,Liu, Yanan

, p. 231 - 235 (2014/05/06)

24(28)-Methylene-1α-hydroxyvitamin D3 was synthesised in 13 steps from vitamin D2. The key step of the synthesis involved the Wittig-Horner olefination of a nor-vitamin D2 aldehyde with diethylphosphono-3-methyl-2-butanone

Synthesis and biological evaluation of a new vitamin D2 analogue

Gandara, Zoila,Perez, Manuel,Salomon, Debora G.,Ferronato, Maria J.,Fermento, Maria E.,Curino, Alejandro C.,Facchinetti, Maria M.,Gomez, Generosa,Fall, Yagamare

, p. 6276 - 6279 (2012/10/30)

A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.

Stereoselective synthesis of (22Z)-25-hydroxyvitamin D2 and (22Z)-1α,25-dihydroxyvitamin D2

Gándara, Zoila,Pérez, Manuel,Pérez-García, Xenxo,Gómez, Generosa,Fall, Yagamare

scheme or table, p. 4874 - 4877 (2009/11/30)

Two new vitamin D2 analogues, (22Z)-25-(OH)-D2 and (22Z)-1α,25-(OH)2-D2, were serendipitously synthesized from vitamin D2 and using the Julia-Kocienski olefination.

Synthesis of a Biologically Active Vitamine-D2 Metabolite

Choudhry, Satish C.,Belica, Peter S.,Coffen, David L.,Focella, Antonino,Maehr, Hubert,et al.

, p. 1496 - 1500 (2007/10/02)

The synthesis of 1α,25,28-trihydroxyvitamin-D2 (1) from vitamin-D2 is described.Approaches to the upper side-chain synthon via the chiral sulfone 15, prepared either through the enzymatic resolution of 10 or the opening of the optica

Process route upstream and downstream products

Process route

(6S)- and (6R)-SO<sub>2</sub> adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10<sup>(19)</sup>-triene
266686-81-1

(6S)- and (6R)-SO2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethanol; for 2h; Inert atmosphere; Reflux;
With sodium hydrogencarbonate; In ethanol; at 75 - 85 ℃;
11 g
(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(E),7(E),10(19)-triene
128387-35-9

(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(E),7(E),10(19)-triene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; Molecular sieve;
95%
With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; Molecular sieve;
95%
(6S)- and (6R)-SO<sub>2</sub> adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10<sup>(19)</sup>-triene
266686-81-1

(6S)- and (6R)-SO2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene
115648-67-4

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethanol; water; for 1.5h; Yields of byproduct given; Heating;
63%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
Multi-step reaction with 7 steps
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps
1.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C
2.1: sulfur dioxide / dichloromethane / 1 h / -20 - -10 °C
3.1: ozone / dichloromethane; tetrahydrofuran / -80 - -65 °C
3.2: 0.5 h / 20 °C
4.1: sodium hydrogencarbonate / ethanol / 75 - 85 °C
With 1H-imidazole; sulfur dioxide; sodium hydrogencarbonate; ozone; In tetrahydrofuran; ethanol; dichloromethane;
1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10<sup>(19)</sup>,22(E)-tetraene
115540-28-8,125136-23-4,111594-58-2,184851-16-9

1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: liq. SO2 / diethyl ether / 0.5 h / Heating
2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
3: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With sulfur dioxide; sodium hydrogencarbonate; ozone; triphenylphosphine; In diethyl ether; ethanol;
Multi-step reaction with 3 steps
1: liq. SO2 / diethyl ether / 0.5 h / Heating
2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
3: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With sulfur dioxide; sodium hydrogencarbonate; ozone; triphenylphosphine; In diethyl ether; ethanol;
Multi-step reaction with 3 steps
1.1: sulfur dioxide / dichloromethane / 1 h / -20 - -10 °C
2.1: ozone / dichloromethane; tetrahydrofuran / -80 - -65 °C
2.2: 0.5 h / 20 °C
3.1: sodium hydrogencarbonate / ethanol / 75 - 85 °C
With sulfur dioxide; sodium hydrogencarbonate; ozone; In tetrahydrofuran; ethanol; dichloromethane;
(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ<sup>6</sup>-benzo[c]thiophen-5-ol
87680-65-7

(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-5-ol

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
Multi-step reaction with 7 steps
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 7 steps
1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
4: imidazole / dimethylformamide / 1.5 h / 20 °C
5: liq. SO2 / diethyl ether / 0.5 h / Heating
6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
(7Z)-Vitamin D<sub>2</sub>
247900-07-8

(7Z)-Vitamin D2

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
Multi-step reaction with 8 steps
1: liq. SO2 / 0.5 h / Heating
2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
4: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
5: imidazole / dimethylformamide / 1.5 h / 20 °C
6: liq. SO2 / diethyl ether / 0.5 h / Heating
7: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
8: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 8 steps
1: liq. SO2 / 0.5 h / Heating
2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
4: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
5: imidazole / dimethylformamide / 1.5 h / 20 °C
6: liq. SO2 / diethyl ether / 0.5 h / Heating
7: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
8: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 8 steps
1: liq. SO2 / 0.5 h / Heating
2: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
4: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
5: imidazole / dimethylformamide / 1.5 h / 20 °C
6: liq. SO2 / diethyl ether / 0.5 h / Heating
7: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
8: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 8 steps
1: liq. SO2 / 0.5 h / Heating
2: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating
4: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating
5: imidazole / dimethylformamide / 1.5 h / 20 °C
6: liq. SO2 / diethyl ether / 0.5 h / Heating
7: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C
8: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating
With 1H-imidazole; selenium(IV) oxide; sulfur dioxide; sodium hydrogencarbonate; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
(6R)-SO<sub>2</sub> adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10<sup>(19)</sup>-triene
112790-51-9,266686-81-1

(6R)-SO2 adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene
115648-67-4

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethanol; for 1.5h; Heating;
5%
90%
(6S)-SO<sub>2</sub> adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10<sup>(19)</sup>-triene
112670-80-1,266686-81-1

(6S)-SO2 adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene
115648-67-4

1(S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(R)-formyl-9,10-secopregna-5(E),7(E),10(19)-triene

Conditions
Conditions Yield
With sodium hydrogencarbonate; In ethanol; for 1.5h; Heating;
5%
90%
1(S),3(R)-3-(tert-butyldimethylsilyl)-9,10-secoergosta-5(E),7(E),10<sup>(19)</sup>,22(E)-tetraene-1-ol
112670-78-7,115540-27-7,132152-22-8

1(S),3(R)-3-(tert-butyldimethylsilyl)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene-1-ol

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al
112828-13-4

(5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 95 percent
2: 94 percent / AIBN, 1.6 eq. Bu3SnH / benzene / 0.5 h / Heating
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene;
Multi-step reaction with 2 steps
1: 93 percent
2: 41 percent / AIBN, 1.6 eq. Bu3SnH / benzene / 0.5 h / Heating
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene;

Global suppliers and manufacturers

Global( 4) Suppliers
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  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Boc Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
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