113231-14-4Relevant articles and documents
A new efficient resveratrol synthesis
Guiso, Marcella,Marra, Carolina,Farina, Angela
, p. 597 - 598 (2002)
The (E)-3,4′,5-trihydroxystilbene (resveratrol) was synthesised via Heck reaction in few steps and with an overall 70% yield.
Phenolic Bis-styrylbenzo[ c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of Aβ Plaque Heterogeneity
Zhang, Jun,Konsmo, Audun,Sandberg, Alexander,Wu, Xiongyu,Nystr?m, Sofie,Obermüller, Ulrike,Wegenast-Braun, Bettina M.,Konradsson, Peter,Lindgren, Mikael,Hammarstr?m, Per
, p. 2038 - 2048 (2019/02/26)
A fluorescent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analogue) showed lower binding affinity toward Aβ1-42 and Aβ1-40 fibrils than its neutral analogue. Hence, variable patterns of neutral OH-substituted bis-styryl-BTDs were generated. All bis-styryl-BTDs showed higher binding affinity to Aβ1-42 fibrils than to Aβ1-40 fibrils. The para-OH on the phenyl rings was beneficial for binding affinity while a meta-OH decreased the affinity. Differential staining of transgenic mouse Aβ amyloid plaque cores compared to peripheral coronas using neutral compared to anionic bis-styryl ligands indicate differential recognition of amyloid polymorphs. Hyperspectral imaging of transgenic mouse Aβ plaque stained with uncharged para-hydroxyl substituted bis-styryl-BTD implicated differences in binding site polarity of polymorphic amyloid plaque. Most properties of the corresponding bis-styryl-BTD were retained with a rigid alkyne linker rendering a probe insensitive to cis-trans isomerization. These new BTD-based ligands are promising probes for spectral imaging of different Aβ fibril polymorphs.
