115-38-8 Usage
Chemical Properties
White Crystalline Solid
Originator
Isonal, Roussel
Uses
Controlled substance (depressant). Anticonvulsant; sedative; hypnotic
Definition
ChEBI: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups.
Manufacturing Process
46 parts metallic sodium was dissolved in 1000 parts absolute alcohol. The obtained solution was mixed with 264 parts of phenyl ethyl malonic acid diethyl ester and 80 parts of monomethyl urea and heated for 8 hours at reflux. Alcohol was distilled off, the residue was dissolved in water and neutralized with diluted sulfuric acid. N-Methylethylphenylbarbituric acid precipitated as a powder. It was filtered off, washed to neutral and dissolved in 50 parts of boiling alcohol. On cooling the obtained methylphenobarbital precipitated as the colorless prisms. MP: 176.5°C. This compound may be also prepared by condensation of equivalents of phenyl malonic ester and monomethyl urea, which was dissolved in above described solution of sodium ethylate.
Brand name
Mebaral (Sterling Winthrop); Menta-Bal (Marion Merrell Dow).
Therapeutic Function
Anticonvulsant
General Description
Mephobarbital, 3-methyl-5-ethyl-5-phenylbarbituric acid (metharbital), is metabolicallyN-demethylated to phenobarbital, which many consider toaccount for almost all of the activity. Its principal use is asan anticonvulsant.
Clinical Use
Mephobarbital is a barbiturate-derivative AED with a pKa of 7.7 (log P = 1.84 at pH 7.4). Approximately 50% of an oral dose of
mephobarbital is absorbed from the gastrointestinal tract. The plasma concentrations required for its therapeutic effects are
unknown. The principal route of mephobarbital metabolism is N-demethylation by the liver to form phenobarbital, which may be
excreted in the urine unchanged and as its p-hydroxy metabolite and glucuronide or sulfate conjugates.
Conversion to the 4-hydroxy metabolite is stereoselective, being catalyzed by either CYP2C19 (R-enantiomer) or CYP2B6
(S-enantiomer); individuals who are CYP2C19 poor metabolizers show decreased clearance. Approximately 75% of a
single oral dose of mephobarbital is converted to phenobarbital. It has not been determined whether mephobarbital contributes
to the antiseizure effect or whether it results from its active metabolite, phenobarbital. Similarly, it is unclear whether
mephobarbital, like phenobarbital, is a potent inducer of the enzymes involved in the metabolism of other drugs, but because
the drug is chemically and pharmacologically similar to phenobarbital and is metabolized to phenobarbital, this possibility is
likely.
Mephobarbital is less commonly used in the treatment of generalized and partial seizures. Like phenobarbital, it is classified as
a long-acting barbiturate. No evidence exists that it is more effective than phenobarbital in equivalent doses; however, it may
be less sedating in children.
Safety Profile
Poison by ingestion and
intraperitoneal routes. A human teratogen
by an unspecified route with developmental
abnormalities of the cardovascular
(circulatory) system. When heated to
decomposition it emits toxic NOx. See also
BARBITURATES.
Check Digit Verification of cas no
The CAS Registry Mumber 115-38-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 115-38:
(5*1)+(4*1)+(3*5)+(2*3)+(1*8)=38
38 % 10 = 8
So 115-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)
115-38-8Relevant articles and documents
A high purity 1 - methyl -5 - ethyl -5 - phenyl barbituric acid preparation method
-
Paragraph 0017-0028, (2019/05/15)
The purpose of this invention is to provide a process for preparing high-purity 1 - methyl - 5 - ethyl - 5 - phenyl barbituric acid (hereinafter mentioned as compound I) preparation method, comprises two steps: A, α - ethyl - α - phenyl malonic acid diethyl (hereinafter mentioned as compound III) in the presence of a methanol solution of sodium methoxide, the role of the methylluracil prepared with 1 - methyl - 5 - ethyl - 5 - phenyl barbiturics acid sodium (hereinafter mentioned as compound II); compound II in hydrochloric acid to acidification to prepare the compounds I to the crude; B, the above obtained compound I for ethanol aqueous solution of the crude product recrystallized to obtain compound I of the exquisite; the process is stable, easy control of reaction conditions, the product quality is stable, the obtained crude product HPLC content of 99.0% or more, by one-time of the product after purifying>HPLC purity 99.9%, high yield, low production cost, is more suitable for industrial production.
Methylation of 5-ethyl-5-phenyl-2-thioxo-4,6(1H,3H,5H)-pyrimidinedione
Kubaszek, M.,Paluchowska, M.,Chmiel, E.,Bojarski, J.
, p. 117 - 124 (2007/10/02)
Methylation of the title compound (2-thiophenobarbital) under different conditions yielded two pairs of isomeric N-, and S--monomethyl and N,N'- and N,S-dimethyl derivatives.Spectral data confirm their structure and allow to identify the methyl substitution.Preliminary results of irradiation of N-CH3 substituted compounds are also presented. Key words: pyrimidines, sulfur compounds, 2-thiobarbiturate
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