116700-36-8

Basic information

• Product Name: H-9 DIHYDROCHLORIDE
• Synonyms: H-9 DIHYDROCHLORIDE;H-9;N-(2-AMINOETHYL)ISOQUINOLINE-5-SULPHONAMIDE DIHYDROCHLORIDE;N-(2-AMINOETHYL)-5-ISOQUINOLINESULFONAMIDE 2HCL;N-(2-AMINOETHYL)-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE;N-(2-aminoethyl)-5-isoquinoline-*sulfonamide hydr;HBLCYSFLYMHCBM-UHFFFAOYSA-N
• CAS NO: 116700-36-8
• Molecular Formula: C₁₁H₁₃N₃O₂S*2ClH
• Molecular Weight: 324.23
• Product Categories: Inhibitors;Protein Kinase Inhibitors and Activators
• Mol File: 116700-36-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 250-255°C dec.
• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: H-9 DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: H-9 DIHYDROCHLORIDE(116700-36-8)
• EPA Substance Registry System: H-9 DIHYDROCHLORIDE(116700-36-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 116700-36-8(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP

Upstream product

• 107-15-3 ethylenediamine 
• 105627-79-0 isoquinoline-5-sulfonyl chloride hydrochloride 
• 84468-15-5 5-isoquinolinesulfonyl chloride 

Downstream Products

• 105628-07-7 fasudil hydrochloride 
• 1453814-94-2 N-{2-[(isoquinoline-5-sulfonyl)amino]ethyl}cyclohexanecarboxamide 
• 116700-44-8 Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride 
• 92564-34-6 HA 1004 hydrochloride 

Relevant articles and documents

Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided

An efficient, robust, and cost-effective synthetic process of fasudil hydrochloride 1 was developed. Starting from readily available ethylenediamine and 5-isoquinoline sulfonyl chloride, the target product 1 was prepared through a six-step reaction, including sulfonamidation, protection, nucleophilic substitution, deprotection, cyclization, and salification. The process afforded 1 in 67.1% overall yield (based on 5-isoquinoline sulfonyl chloride) with 99.94% purity. Compared to the earlier published methodologies, the use of homopiperazine or its derivatives as intermediates was avoided. The salient features of this environmentally friendly synthetic route include easily available starting materials and operational simplicity, which could be suitable for large-scale industrial production.