118358-66-0Relevant articles and documents
Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction
Pianowski, Zbigniew L.,Winssinger, Nicolas
, p. 3820 - 3822 (2007)
Templated reduction of low fluorescence azidocoumarin-PNA conjugate to high fluorescence aminocoumarin was achieved using a catalytic amount of DNA with single nucleotide resolution. The Royal Society of Chemistry.
O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD
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Paragraph 0455-0464, (2022/01/24)
It was discovered that a cyclic sulfamidate can be produced by reacting an amino acid derivative with a cyclization reagent. In addition, it was discovered that an O-substituted serine derivative can be produced by reacting a cyclic sulfamidate with an alcohol.
Progress toward the assembly of the bicyclic theonellamide skeleton
Batton, Chyree S.,Mukherjee, Jyoti P.,Roy, Joyeeta,Taylor, Carol M.,Wong, Douglas,Yadav, Saroj
, (2020/04/01)
An orthogonally protected τ-histidinoalanine residue was synthesized via regioselective alkylation of optically pure Boc-L-His-OTCE (TCE = trichloroethyl) with a sulfamidate electrophile derived from Fmoc-D-Ser-OBn. The goal was the synthesis of a non-natural theonellamide, invoking readily accessible variants of the other 10 amino acids. Peptide fragments corresponding to the east and west rings of “theonellamide X″ were synthesized in solution. Each ring was formed independently, providing insights into protecting group limitations, side reactions, and the optimal order of events to approach the formation of the bicyclic system. Ultimately, an undecapeptide was prepared, with the eastern ring formed. The twelfth amino acid, an L-α-aminoadipic acid building block, was prepared and preliminary investigations into its attachment to the undecapeptide are reported.
COMPOSITIONS AND METHODS OF TREATING CANCER AND INFECTIONS USING BACTERIOPHAGE AND ITS MUTANTS
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Page/Page column 8, (2019/03/17)
Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.
