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118811-07-7

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  • Large Stock 99.0% 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-... 118811-07-7 Producer

    Cas No: 118811-07-7

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118811-07-7 Usage

Description

4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a piperidine derivative featuring a piperidine ring with a tert-butyl ester group and a toluene-4-sulfonyloxy group. This chemical compound is recognized for its unique structure and reactivity, making it a valuable building block in organic synthesis and pharmaceutical research for the development of bioactive molecules and novel therapeutic agents for various medical conditions.

Uses

Used in Pharmaceutical Research:
4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block for the synthesis of bioactive molecules, contributing to the discovery and development of new drugs for a wide range of medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized for the creation of complex organic compounds, leveraging its unique reactivity and structural features to facilitate the synthesis of target molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 118811-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,8,1 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 118811-07:
(8*1)+(7*1)+(6*8)+(5*8)+(4*1)+(3*1)+(2*0)+(1*7)=117
117 % 10 = 7
So 118811-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H25NO5S/c1-13-5-7-15(8-6-13)24(20,21)23-14-9-11-18(12-10-14)16(19)22-17(2,3)4/h5-8,14H,9-12H2,1-4H3

118811-07-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Toluene-4-Sulfonyloxy)-Piperidine-1-Carboxylic Acid Tert-Butyl Ester

1.2 Other means of identification

Product number -
Other names tert-Butyl 4-(p-Toluenesulfonyloxy)piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118811-07-7 SDS

118811-07-7Relevant articles and documents

Discovery and optimization of a potent and selective indazolamine series of IRAK4 inhibitors

Zhai, Wenqiang,Lu, Yongping,Zhu, Yabo,Zhou, Mengguang,Ye, Cheng,Shi, Zheng-Zheng,Qian, Wenjian,Hu, Taishan,Chen, Lei

, (2021)

IRAK4 is a key mediator of innate immunity. There is a high interest in identifying novel IRAK4 inhibitors for the treatment of inflammatory autoimmune diseases. We describe here a highly potent and selective IRAK4 inhibitor (HS271) that exhibited superio

Thienopyrimidine derivatives and preparation method thereof

-

Paragraph 0128-0129; 0146-0147, (2021/09/08)

Disclosed are a thienopyrimidine derivative and a preparation method therefor. Provided is a method for preparing a compound as shown in formula B, which method is characterized by comprising the following steps: subjecting a compound as shown in formula

1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition

Achanta, Pramod Kumar,Badange, Rajesh Kumar,Benade, Vijay,Bojja, Kumar,Choudary Palacharla, Raghava,Jayarajan, Pradeep,Kagita, Narendra,Lingavarapu, Bujji Babu,Manchineella, Sravanthi,Mohammed, Abdul Rasheed,Nirogi, Ramakrishna,Rao Doguparthi, Mallikarjuna,Rao Muddana, Nageswara,Reballi, Veena,Shinde, Anil Karbhari,Subramanian, Ramkumar,Thentu, Jagadeesh Babu,Yarra, Sivasekhar

, (2021/11/23)

A series of chemical optimizations, which was guided by in vitro affinity at histamine H3 receptor (H3R), modulation of lipophilicity, ADME properties and preclinical efficacy resulted in the identification of 1-[2-(1-cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one (45 e) as a potent and selective (Ki=4.0 nM) H3R inverse agonist. Dipsogenia induced by (R)-α-methylhistamine was dose dependently antagonized by 45 e, confirming its functional antagonism at H3R. It is devoid of hERG and phospholipidosis issues. Compound 45 e has adequate oral exposures and favorable half-life in both rats and dogs. It has demonstrated high receptor occupancy (ED80=0.22 mg/kg) and robust efficacy in object recognition task and, dose dependently increased acetylcholine levels in brain. The sub-therapeutic doses of 45 e in combination with donepezil significantly increased acetylcholine levels. The potent affinity, selectivity, in vivo efficacy and drug like properties together with safety, warrant for further development of this molecule for potential treatment of cognitive disorders associated with Alzheimer's disease.

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