119302-20-4 Usage
Description
(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol is a complex organic compound with a unique molecular structure. It is characterized by its white solid appearance and is known for its role in the synthesis of pharmaceutical agents.
Uses
Used in Pharmaceutical Industry:
(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol is used as an intermediate in the synthesis of neuromuscular blocking agents, specifically for the production of rocuronium bromide. (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol plays a crucial role in the development of medications that are essential for surgical procedures, as they help to facilitate muscle relaxation and ensure patient safety during operations.
Chemical Properties:
(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol is a white solid, which indicates its stable and solid-state nature. Its chemical properties contribute to its utility in the pharmaceutical industry, particularly in the synthesis of neuromuscular blocking agents.
Check Digit Verification of cas no
The CAS Registry Mumber 119302-20-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,3,0 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 119302-20:
(8*1)+(7*1)+(6*9)+(5*3)+(4*0)+(3*2)+(2*2)+(1*0)=94
94 % 10 = 4
So 119302-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H46N2O3/c1-26-8-7-20-19(21(26)16-22(25(26)31)28-9-3-4-10-28)6-5-18-15-24(30)23(17-27(18,20)2)29-11-13-32-14-12-29/h18-25,30-31H,3-17H2,1-2H3/t18-,19+,20-,21-,22-,23-,24-,25-,26-,27-/m0/s1
119302-20-4Relevant articles and documents
A new and efficient method for the synthesis of rocuronium bromide
Wu, Xue-Ying,Wang, Yao-Ling,Hai, Li,Gong, Ping,Wu, Yong
, p. 487 - 492 (2017)
Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α,17β-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove.
Processes for the synthesis of rocuronium bromide
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Page/Page column 14, (2008/06/13)
The invention encompasses processes for synthesizing 1-[17β-acetyloxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof.
Novel 2β-morpholino-androstane derivatives
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, (2008/06/13)
Compounds having the formula: STR1 wherein R 1 is H or an optionally substituted acyl group having 1-12 carbon atoms,R 2 is H or an acyl group having 1-12 carbon atoms andR 3 is C, N--CH 3 or a direct bond;and mono- or bisquaternary ammonium compounds thereof and acid addition salts of the non- or mono-quaternary ammonium compounds. Process for the preparation of these compounds. Compositions comprising at least one of the above compounds as the active ingredient. The compounds are favorable neuromuscular blocking agents.