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CAS

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119793-66-7

Propionyl-L-carnitine hydrochloride is a naturally occurring carnitine derivative that plays a crucial role in the metabolism of fatty acids and the maintenance of cardiovascular health. It is formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids and exhibits various beneficial effects on the heart and blood vessels.

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    Cas No: 119793-66-7

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  • 119793-66-7 Structure

  • Basic information

    1. Product Name: Propionyl-L-carnitine hydrochloride
    2. Synonyms: PROPIONYL-L-CARNITINE CHLORIDE;PROPIONYL L-CARNITINE HCL;PROPIONYL-L-CARNITINE HYDROCHLORIDE;PROPIONYL-LEVO-CARNITINE HYDROCHLORIDE;(r)-2-propionyl-3-(trimethylaminium)butanoic acid chloride;Propionyl L-Carnitine;PROPIONYLLEVOCARNITINE HCL;Propionyllevocarnitine
    3. CAS NO:119793-66-7
    4. Molecular Formula: C10H20NO4*Cl
    5. Molecular Weight: 253.72
    6. EINECS: 1308068-626-2
    7. Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;ALDOMET
    8. Mol File: 119793-66-7.mol

  • Chemical Properties

    1. Melting Point: 165-167°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Store at 0°C
    8. Solubility: Chloroform (Slightly), Water (Slightly)
    9. Stability: Hygroscopic
    10. CAS DataBase Reference: Propionyl-L-carnitine hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: Propionyl-L-carnitine hydrochloride(119793-66-7)
    12. EPA Substance Registry System: Propionyl-L-carnitine hydrochloride(119793-66-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 119793-66-7(Hazardous Substances Data)

119793-66-7 Usage

Uses

Used in Pharmaceutical Industry:
Propionyl-L-carnitine hydrochloride is used as an antihypertensive agent for its ability to help regulate blood pressure and improve cardiovascular health.
Used in Cardiology:
Propionyl-L-carnitine hydrochloride is used as a therapeutic agent for improving the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion. It helps in reducing mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores.
Used in Cardiovascular Research:
Propionyl-L-carnitine hydrochloride is used as a research compound for studying its effects on the cardiovascular system, including its role in reducing the production of reactive oxygen species (ROS) and decreasing the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs).
Chemical Properties:
Propionyl-L-carnitine hydrochloride is a white solid with specific chemical properties that contribute to its effectiveness in various applications.
Brand Name:
One of the brand names for Propionyl-L-carnitine hydrochloride is Drosos, manufactured by Biosint S.p.A.

Check Digit Verification of cas no

The CAS Registry Mumber 119793-66-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,7,9 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 119793-66:
(8*1)+(7*1)+(6*9)+(5*7)+(4*9)+(3*3)+(2*6)+(1*6)=167
167 % 10 = 7
So 119793-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H19NO4.ClH/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4;/h8H,5-7H2,1-4H3;1H/t8-;/m1./s1

119793-66-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-Propionyl Carnitine Chloride

1.2 Other means of identification

Product number -
Other names [(2R)-3-carboxy-2-propanoyloxypropyl]-trimethylazanium,chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119793-66-7 SDS

119793-66-7Synthetic route

propionyl chloride
79-03-8

propionyl chloride

L-carnitine chloride
6645-46-1

L-carnitine chloride

(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride
119793-66-7

(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride

Conditions
ConditionsYield
With trifluoroacetic acid at 40 - 50℃; for 20h;
(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride
119793-66-7

(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride

glycine
56-40-6

glycine

glycine propionyl-L-carnitine hydrochloride

glycine propionyl-L-carnitine hydrochloride

Conditions
ConditionsYield
Stage #1: (R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride In ethanol at 50℃;
Stage #2: glycine In ethanol at 70℃; for 2h; Concentration; Temperature; Solvent;		98.7%
(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride
119793-66-7

(R)-3-carboxy-N,N,N-trimethyl-2-(propionyloxy)propan-1-ammonium chloride

C10H19ClNO3(1+)*Cl(1-)

C10H19ClNO3(1+)*Cl(1-)

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane at 40 - 50℃;

119793-66-7Downstream Products

119793-66-7Relevant articles and documents

Synthesis of carnitine benzyl esters as prodrugs

Gong, Xiao-Wei,Li, Jin-Pei,Wu, Ji-Feng,Li, Xun,Zhai, Hai-Min,Feng, Bo,Xu, Wen-Fang,Tang, Wei

experimental part, p. 327 - 330 (2009/05/30)

The introduction of C-2 acyl groups and a benzyl ester onto L-carnitine generated a series of carnitine benzyl esters as prodrug with improved liposolubility, stability and bioavailability.

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