120219-17-2 Usage
Uses
Used in Organic Synthesis:
(2S,3S)-2-Isocyanato-3-methylvaleric acid methyl ester is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique chiral isocyanate structure allows for the formation of diverse chemical entities, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2S,3S)-2-Isocyanato-3-methylvaleric acid methyl ester is utilized as a precursor for the development of chiral drugs. Its chiral center plays a crucial role in the synthesis of enantiomerically pure compounds, which are essential for the production of effective and safe medications. (2S,3S)-2-ISOCYANATO-3-METHYLVALERIC ACID METHYL ESTER's reactivity and selectivity in various chemical reactions enable the creation of novel pharmaceutical agents with improved therapeutic properties.
Used in Materials Science:
(2S,3S)-2-Isocyanato-3-methylvaleric acid methyl ester also finds applications in materials science, particularly in the development of advanced polymers and coatings. Its isocyanate functionality allows for the formation of urethane linkages, which are known for their excellent mechanical properties, thermal stability, and chemical resistance. This makes the compound a promising candidate for the synthesis of high-performance materials used in various industries, such as automotive, aerospace, and electronics.
Check Digit Verification of cas no
The CAS Registry Mumber 120219-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,1 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 120219-17:
(8*1)+(7*2)+(6*0)+(5*2)+(4*1)+(3*9)+(2*1)+(1*7)=72
72 % 10 = 2
So 120219-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO3/c1-4-6(2)7(9-5-10)8(11)12-3/h6-7H,4H2,1-3H3/t6-,7-/m0/s1
120219-17-2Relevant articles and documents
Synthesis of N-Acylamino-Acid Derivatives of Cytisine
Yazlovitskii,Garazd,Kartsev
, p. 272 - 275 (2016/07/06)
N-acylamino-acid derivatives of cytisine were prepared by reacting cytisine with methyl esters of aminoacid isocyanates.
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
Su, Li,Jia, Yuping,Zhang, Lei,Xu, Yingying,Fang, Hao,Xu, Wenfang
experimental part, p. 3807 - 3815 (2012/08/27)
A series of amino acid ureido derivatives as aminopeptidase N (APN/CD13) inhibitors were synthesized and evaluated for their APN inhibitory activities and anti-cancer effects. The results showed that most of these amino acid ureido derivatives exhibited good inhibition against APN, several of which were better than Bestatin. The most active compound 12j (IC50 = 1.1 μM, compared with Bestatin IC50 = 8.1 μM) not only possessed much better APN inhibitory activity and anti-proliferation effect on cancer cells, but also exhibited significant block effect of human cancer cell invasion compared with the positive control, Bestatin. These amino acid ureido derivatives could be possibly developed as new APN inhibitors for cancer chemotherapy in the future.
Isocyanates, Part 4.10 Convenient Phosgene-Free Method for the Synthesis and Derivatization of Enantiopure α-Isocyanato Carboxylic Acid Esters
Kn?lker, Hans-Joachim,Braxmeier, Tobias
, p. 925 - 928 (2007/10/03)
A novel phosgene-free procedure for the synthesis of α-isocyanato carboxylic acid esters starting from α-amino acid esters has been achieved. The isocyanates are obtained enantiomerically pure (> 99% ee) by a DMAP-catalyzed isocyanation with di-tert-butyl
