120363-13-5Relevant articles and documents
CBTF: New amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability
Kolodych, Sergii,Koniev, Oleksandr,Baatarkhuu, Zoljargal,Bonnefoy, Jean-Yves,Debaene, Fran?ois,Cianférani, Sarah,Van Dorsselaer, Alain,Wagner, Alain
, p. 197 - 200 (2015)
Amine-to-thiol coupling is the most common route for the preparation of antibody-drug conjugates (ADC). It is usually achieved by using heterobifunctional reagents possessing an activated ester at one end and a maleimide group at the other. However, malei
A New Class of Rigid Multi(azobenzene) Switches Featuring Electronic Decoupling: Unravelling the Isomerization in Individual Photochromes
Galanti, Agostino,Santoro, Jasmin,Mannancherry, Rajesh,Duez, Quentin,Diez-Cabanes, Valentin,Valá?ek, Michal,De Winter, Julien,Cornil, Jér?me,Gerbaux, Pascal,Mayor, Marcel,Samorì, Paolo
supporting information, p. 9273 - 9283 (2019/06/07)
We report a novel class of star-shaped multiazobenzene photoswitches comprising individual photochromes connected to a central trisubstituted 1,3,5-benzene core. The unique design of such C3-symmetric molecules, consisting of conformationally r
NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT
-
Paragraph 0116, (2018/06/07)
The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, comprising same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.