1219454-89-3

Basic information

• Product Name: Pyridine, 2-[(difluoroMethyl)sulfonyl]-
• Synonyms: Pyridine, 2-[(difluoroMethyl)sulfonyl]-;2-[(DifluoroMethyl)sulfonyl]pyridine;DifluoroMethyl 2-Pyridyl Sulfone;2-PySO2CF2H;Hu Reagent;Difluoromethyl 2-pyridyl sulfone 97% (HPLC);2-(Difluoromethanesulfonyl)pyridine
• CAS NO: 1219454-89-3
• Molecular Formula: C₆H₅F₂NO₂S
• Molecular Weight: 193.1712064
• EINECS: -0
• Product Categories: Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 1219454-89-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 47.0 to 51.0 °C
• Boiling Point: 324.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -2.60±0.19(Predicted)
• BRN: 20317604
• CAS DataBase Reference: Pyridine, 2-[(difluoroMethyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-[(difluoroMethyl)sulfonyl]-(1219454-89-3)
• EPA Substance Registry System: Pyridine, 2-[(difluoroMethyl)sulfonyl]-(1219454-89-3)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45-24/25
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1219454-89-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1219454-89-3 differently. You can refer to the following data:
1. 2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
2. Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.

General Description

Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.

Upstream product

• 28856-92-0 (Ethoxycarbonyl)methyl 2-pyridyl sulfide 
• 2637-34-5 pyridine-2-thione 
• 2637-34-5 2-Sulfanylpyridine 

Downstream Products

• 142-08-5 2-hydroxypyridin 
• 134134-76-2 (4,4-difluorobut-3-en-1-yl)benzene 
• 253266-72-7 5-(2,2-difluorovinyl)benzo[d][1,3]dioxole 
• 149683-62-5 (4,4-difluoro-3-methyl-3-buten-1-yl)benzene 
• 208245-65-2 4-(difluoromethylene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 83567-84-4 4-bromo-β,β-difluoro-α-methylstyrene 
• 84750-94-7 1-(2,2-difluorovinyl)-3-nitrobenzene 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 1219454-96-2 C₁₅H₁₅F₂NO₄S 
• 84750-93-6 1,1-difluoro-2-(4-bromophenyl)ethene 
• 131581-40-3 1,1-difluoro-2-(2-naphthyl)ethene 
• 28321-12-2 (E)-(4,4-difluorobuta-1,3-diene-1-yl)benzene 
• 38935-94-3 4-dimethylamino-β,β-difluorostyrene 
• 1219454-94-0 (E)-(4,4-difluoro-3-methylbuta-1,3-dienyl)benzene 

Relevant articles and documents

Direct synthesis of fluorinated heteroarylether bioisosteres

(Bioiso)steering in a new direction: A modular synthesis of reagents (e.g. sodium difluoroethylsulfinate) that can be used for the direct incorporation of difluoroalkyl groups onto heterocycles is reported. The scope and generality of the incorporation of

Modified Julia olefination on sugar-derived lactones: Synthesis of difluoro exo-glycals

We report the preparation of difluoro-exo-glycals by gem-difluoroolefination of benzylated sugar-derived lactones using a modified Julia reaction. The addition is highly stereo-selective, and the Smiles-rearrangement-elimination sequence can be carried out under microwave irradiation.

Difluoromethyl 2-pyridyl sulfone: A new gem-difluoroolefination reagent for aldehydes and ketones

Chemical equation presented Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was found that the fluorinated sulfinate intermediate in the reaction is relatively stable, which can be observed by 19F NMR and trapped with CH 3l.