134134-76-2

Basic information

• Product Name: (4,4-Difluoro-3-buten-1-yl)benzene
• Synonyms: (4,4-Difluoro-3-buten-1-yl)benzene
• CAS NO: 134134-76-2
• Molecular Formula: C₁₀H₁₀F₂
• Molecular Weight: 168.1832064
• Mol File: 134134-76-2.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 178.858 °C at 760 mmHg
• Flash Point: 48.758 °C
• Appearance: /
• Density: 1.054 g/cm³
• CAS DataBase Reference: (4,4-Difluoro-3-buten-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (4,4-Difluoro-3-buten-1-yl)benzene(134134-76-2)
• EPA Substance Registry System: (4,4-Difluoro-3-buten-1-yl)benzene(134134-76-2)

Safety Data

• Hazardous Substances Data: 134134-76-2(Hazardous Substances Data)

Usage

General Description

(4,4-Difluoro-3-buten-1-yl)benzene, also known as difluorobutenylbenzene, is an organic compound with the chemical formula C10H8F2. It contains a benzene ring with a substituted 3-buten-1-yl group, in which two of the hydrogen atoms have been replaced by fluorine atoms. (4,4-Difluoro-3-buten-1-yl)benzene is commonly used in organic synthesis and chemical research as a building block for the creation of more complex organic molecules. It has a variety of industrial applications, including as a starting material in the production of pharmaceuticals, agrochemicals, and materials used in the electronics industry. Additionally, (4,4-Difluoro-3-buten-1-yl)benzene is an important reagent in the development of new materials and technologies.

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 34420-17-2 (2-phenylethyl)boronic acid 
• 2236129-81-8 trifluoroacetaldehyde N-triftosylhydrazone 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 1895-39-2 sodium chlorodifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 642-31-9 9-anthracene aldehyde 
• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 
• 1600503-70-5 potassium 2-pyridinyl sulfonyl-difluoroacetate 
• 75-45-6 Chlorodifluoromethane 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 100-42-5 styrene 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 

Relevant articles and documents

Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions

A deoxygenative difluoromethylenation of carbonyl compounds has been developed by using readily available, inexpensive trifluoromethyltrimethylsilane, LiI, and PPh3. The presence of the Li+ion prevents the unproductive exhaustion of trifluoromethyltrimethylsilane (TMSCF3) by keeping the soluble free fluoride concentration in the reaction medium under control. The strategy of combining solvents to increase the reactivity and thereby reduce the reaction temperature and time is disclosed.

Design and Synthesis of TY-Phos and Application in Palladium-Catalyzed Enantioselective Fluoroarylation of gem-Difluoroalkenes

The first example of highly enantioselective fluoroarylation of gem-difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine (Sadphos) type ligand TY-Phos. N-Me-TY-Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily available starting materials, good yields, high enantioselectivities as well as broad substrate scope make this approach very practical and attractive. Notably, the asymmetric synthesis of an analogue of a biologically active molecule is also reported.

Pd-Catalyzed Selective Carbonylation of gem-Difluoroalkenes: A Practical Synthesis of Difluoromethylated Esters

The first catalyst for the alkoxycarbonylation of gem-difluoroalkenes is described. This novel catalytic transformation proceeds in the presence of Pd(acac)2/1,2-bis((di-tert-butylphosphan-yl)methyl)benzene (btbpx) (L4) and allows for an efficient and straightforward access to a range of difluoromethylated esters in high yields and regioselectivities. The synthetic utility of the protocol is showcased in the practical synthesis of a Cyclandelate analogue using this methodology as the key step.