1254782-72-3

Basic information

• Product Name: C₂₄H₃₀N₈O₂
• CAS NO: 1254782-72-3
• Molecular Weight: 462.555
• Mol File: 1254782-72-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₀N₈O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₀N₈O₂(1254782-72-3)
• EPA Substance Registry System: C₂₄H₃₀N₈O₂(1254782-72-3)

Safety Data

• Hazardous Substances Data: 1254782-72-3(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 90918-78-8 N-methyl-N-(4-nitrophenyl)propionamide 
• 4850-93-5 N-(4-nitrophenyl)propionamide 
• 814-68-6 acryloyl chloride 
• 112077-95-9 N-(4-aminophenyl)-N-methylpropionamide 

Relevant articles and documents

Discovery of selective irreversible inhibitors for EGFR-T790M

Targeting the epidermal growth factor receptor kinase (EGFR) with ATP-competitive kinase inhibitors results in dramatic but short-lived responses in patients with EGFR mutant non small cell lung cancer. A series of novel covalent EGFR kinase inhibitors with selectivity for the clinically relevant T790M 'gatekeeper' resistance mutation relative to wild-type EGFR were discovered by library screening. A representative compound 3i was obtained through a systematic SAR study guided by mutant EGFR-dependent cellular proliferation assays.