1262036-49-6 Usage
Uses
Used in Pharmaceutical Drug Development:
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique chemical structure, including the furothiazinylphenyl moiety and fluorine atoms, may contribute to its pharmacological activity and therapeutic potential.
Used in Medicinal Chemistry Research:
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride serves as a valuable research tool in medicinal chemistry, where it can be studied to understand its interactions with biological targets and its potential as a lead compound for drug development. Its structure may provide insights into the design of new molecules with improved pharmacological properties.
Used in Drug Discovery:
N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride is utilized in drug discovery processes to identify novel therapeutic agents. Its unique features may offer new avenues for the treatment of various diseases and conditions, pending further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1262036-49-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,0,3 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1262036-49:
(9*1)+(8*2)+(7*6)+(6*2)+(5*0)+(4*3)+(3*6)+(2*4)+(1*9)=126
126 % 10 = 6
So 1262036-49-6 is a valid CAS Registry Number.
1262036-49-6Relevant articles and documents
Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization
Hansen, Marvin M.,Jarmer, Daniel J.,Arslantas, Enver,DeBaillie, Amy C.,Frederick, Andrea L.,Harding, Molly,Hoard, David W.,Hollister, Adrienne,Huber, Dominique,Kolis, Stanley P.,Kuehne-Willmore, Jennifer E.,Kull, Thomas,Laurila, Michael E.,Linder, Ryan J.,Martin, Thomas J.,Martinelli, Joseph R.,McCulley, Michael J.,Richey, Rachel N.,Starkey, Derek R.,Ward, Jeffrey A.,Zaborenko, Nikolay,Zweifel, Theo
, p. 1214 - 1230 (2015)
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl chir
BACE INHIBITORS
-
Page/Page column 33, (2011/02/15)
The present invention provides BACE inhibitors of Formula I: methods for their use, intermediates, and methods for their preparation.
