717871-83-5

Basic information

• Product Name: 2-Pyridinecarbonyl chloride, 5-fluoro- (9CI)
• Synonyms: 2-Pyridinecarbonyl chloride, 5-fluoro- (9CI);2-Pyridinecarbonyl chloride, 5-fluoro-;5-Fluoropyridine-2-carbonyl chloride
• CAS NO: 717871-83-5
• Molecular Formula: C₆H₃ClFNO
• Molecular Weight: 159.5455232
• Product Categories: ACIDHALIDE
• Mol File: 717871-83-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarbonyl chloride, 5-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonyl chloride, 5-fluoro- (9CI)(717871-83-5)
• EPA Substance Registry System: 2-Pyridinecarbonyl chloride, 5-fluoro- (9CI)(717871-83-5)

Safety Data

• Hazardous Substances Data: 717871-83-5(Hazardous Substances Data)

Upstream product

• 107504-08-5 5-fluoropicolinic acid 
• 453566-94-4 5-fluoropyridine-2-carboxylic acid hydrochloride 

Downstream Products

• 1262036-49-6 N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride 
• 1262036-50-9 N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide 
• 499796-71-3 5-fluoro-2-pyridinecarboxamide 
• 1310807-56-7 ethyl 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-1,2,4-oxadiazole-3-carboxylate 
• 1310805-76-5 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide 
• 1310805-68-5 5-(5-{3-isopropoxy-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy}pyridin-2-yl)-N-methyl-1,2,4-oxadiazole-3-carboxamide 

Relevant articles and documents

Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin

ABTRACT: This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1–e25 have been characterized by 1H NMR, 13C NMR, ESI-MS and elemental analysis. Meanwhile, their agricultural activity have been evaluated in two weeds (Amaranth and Crabgrass) and four widespread noxious pathogens (V.mali, B.cinerea, F.axysporium and C.bacteria). The herbicidal activity results showed that almost all synthetic molecules have a greater impact on the stem system than on the root. Excellent inhibition rates were discovered from compounds e2–e5 and e20–e23 against Amaranth on stems, which were above 58percent(20 mg/L), 68percent(100 mg/L) respectively. Compounds e2 and e21 also exhibited striking inhibition on stems growth of both weeds. Anti-pathogenic activity showed that all the compounds exerted a better inhibitory activity on B.cinerea at 20 ppm compared to control carbendazim. All the heterocyclic substituted compounds (e17–e24, >57percent) made a better influence than the control (54.1percent) at the100 ppm. This research provides promising herbicidal and anti-pathogenic agents that have the better effects and can be potential for further development.

Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore

Inspired by natural 2-quinolinecarboxylic acid derivatives, a series of quinoline compounds containing acylhydrazine, acylhydrazone, sulfonylhydrazine, oxadiazole, thiadiazole, or triazole moieties were synthesized and evaluated for their fungicidal activity. Most of these compounds exhibited excellent fungicidal activity in vitro. Significantly, compound 2e displayed the superior in vitro antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, and Fusarium graminearum with the EC50 values of 0.39, 0.46, 0.19, and 0.18 μg/mL, respectively, and were more potent than those of carbendazim (EC50, 0.68, 0.14, >100, and 0.65 μg/mL, respectively). Moreover, compound 2e could inhibit spore germination of F. graminearum. Preliminary mechanistic studies showed that compound 2e could cause abnormal morphology of cell walls and vacuoles, loss of mitochondrion, increases in membrane permeability, and release of cellular contents. These results indicate that compound 2e displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases.

ANTI-HBVTETRAHYDROISOXAZOLO[4,3-C]PYRIDINE COMPOUNDS

Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).