1300031-60-0Relevant articles and documents
METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
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, (2021/08/13)
The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.
7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives
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, (2014/03/21)
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151
Mirguet, Olivier,Lamotte, Yann,Donche, Frédéric,Toum, Jér?me,Gellibert, Franoise,Bouillot, Anne,Gosmini, Romain,Nguyen, Van-Loc,Delannée, Delphine,Seal, Jonathan,Blandel, Florence,Boullay, Anne-Bénédicte,Boursier, Eric,Martin, Sandrine,Brusq, Jean-Marie,Krysa, Gael,Riou, Alizon,Tellier, Rémi,Costaz, Agns,Huet, Pascal,Dudit, Yann,Trottet, Lionel,Kirilovsky, Jorge,Nicodeme, Edwige
, p. 2963 - 2967 (2012/06/04)
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.
Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors
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, (2012/09/22)
Novel compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
NOVEL COMPOUNDS
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, (2012/11/07)
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS
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, (2011/06/11)
Novel compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.