131420-42-3

Basic information

• Product Name: Brn 4239697
• Synonyms: (R*,S*)-3,3'-(1,2-Ethanediyl)bis(2-(2-pyridinyl)-4-thiazolidinone);4-Thiazolidinone, 3,3'-(1,2-ethanediyl)bis(2-(2-pyridinyl)-, (R*,S*)-;Brn 4239697
• CAS NO: 131420-42-3
• Molecular Formula: C18H18N4O2S2
• Molecular Weight: 386.49112
• Mol File: 131420-42-3.mol

Chemical Properties

• Boiling Point: 722.7°Cat760mmHg
• Flash Point: 390.9°C
• Appearance: /
• Density: 1.38g/cm³
• CAS DataBase Reference: Brn 4239697(CAS DataBase Reference)
• NIST Chemistry Reference: Brn 4239697(131420-42-3)
• EPA Substance Registry System: Brn 4239697(131420-42-3)

Safety Data

• Hazardous Substances Data: 131420-42-3(Hazardous Substances Data)

Upstream product

• 2847-14-5 (1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine) 
• 68-11-1 mercaptoacetic acid 
• 1121-60-4 pyridine-2-carbaldehyde 
• 107-15-3 ethylenediamine 

Downstream Products

• 906513-02-8 C₁₈H₁₈N₄O₆S₂ 

Relevant articles and documents

Nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane as high-performance catalyst for the preparation of bis-thiazolidinones under ultrasonic conditions

We report a class of organic-inorganic hybrid material based on nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane [nano-colloidal silica@APTPOSS (a series of polyhedral oligomeric sils

Nano-CdZr4(PO4)6 as a reusable and robust catalyst for the synthesis of bis-thiazolidinones by a multicomponent reaction of aldehydes, ethylenediamine and thioglycolic acid

Nano-CdZr4(PO4)6 has been used as an efficient catalyst for the preparation of bis-thiazolidinones by pseudo-five-component reaction of aldehydes, ethylenediamine and thioglycolic acid under reflux conditions in toluene. T

Synthesis of Bis-Thiazolidinones Using Chitosan-attached Nano-CuFe2O4 as an Efficient and Retrievable Heterogeneous Catalyst

The preparation of bis-thiazolidinones has been achieved by a one-pot condensation reaction of araldehydes, ethylenediamine, and 2-mercaptoacetic acid in the presence of nano-CuFe2O4@chitosan under reflux conditions in toluene. The c

Synthesis and spectral data of new 1,2-bis-(2-hetaryl-4-oxothiazolidin-3- yl)ethanes and 1,4-bis-(2-hetaryl-4-oxothiazolidin-3-yl)butanes

New α,ω-bis-(2-hetaryl-4-oxothiazolidin-3-yl)alkanes were prepared via a common two step procedure using N,N-bis-hetarylidenamines condensation with α-mercaptoacetic acid. The used bis-aldimines were obtained from reaction between ethylenediamine or putrescine and benzaldehyde or the isomeric pyridinecarboxyaldehydes. The bis-(2-phenyl-4-oxothiazolidin-3-yl) alkanes were prepared by one-pot three component reaction of diamine, aldehyde and α-mercaptoacetic acid under very mild conditions.

3,3'-Di(1,3-triazolidine-4-one) system. V. Synthesis and pharmacological properties of 3,3' (1,2-ethanediyl)bis-(2-heteroaryl-1,3-thiazolidine-4-one) derivatives

A class of anti-inflammatory, analgesic and histamine H1- and H2-receptor antagonists the 2,2'-dihetero-arylbisthiazolidinones and their 1,1'-disulfones, obtained as [RR, SS] and [RS, SR] isomers, is described. The heteroaryl substitution at 2 and 2' carbons generally improves the pharmacological activities with respect to those of the previously studied 2,2'-diaryl analogues. In particular the 2,2'-dithienyl derivatives exhibit analgesic properties and, as [RS, SR] isomers 6b, 11b, 12b H2-histamine receptor antagonism as well. The most effective acute anti-inflammatory agents appear to be the 2,2'-di(3-pyridyl) compounds 8a, 8b, 14a, 14b which also display analgesic activity. Moreover, an H1-histamine receptor antagonism is almost selectively exerted by the 2,2'-di(2-pyridyl) derivatives 7a, 7b, 13a, 13b. The relationships between the assessed activities and the chirality and/or the sulfur oxidation state of the molecules are discussed. The anti-cancer potential was also evaluated against P 388 murine lymphocytic leukemia; however, the results were not significant.