13169-74-9

Basic information

• Product Name: Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)-
• CAS NO: 13169-74-9
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol File: 13169-74-9.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)-(13169-74-9)
• EPA Substance Registry System: Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)-(13169-74-9)

Safety Data

• Hazardous Substances Data: 13169-74-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)is utilized as a key intermediate in organic synthesis for the preparation of complex organic molecules. Its unique structure allows for various chemical reactions, making it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, this compound is employed as a precursor in the development of new drugs. Its potential pharmacological properties make it a promising candidate for the creation of bioactive molecules with therapeutic applications.
Used in Drug Development:
Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)is used as a building block in drug development for the production of pharmaceutical drugs. Its structural features contribute to the design and synthesis of novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Laboratory Research:
Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)is also used in laboratory research settings for its reactivity and selectivity in chemical reactions. It serves as a model compound for studying reaction mechanisms and developing new synthetic methodologies.
Used in Chemical Education:
Ethanone, 2-phenyl-1-(1H-pyrrol-2-yl)is utilized in chemical education to demonstrate the principles of organic chemistry, including the properties of ketones, the reactivity of functional groups, and the synthesis of complex organic molecules.

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 908094-04-2 phenyldiazomethane 
• 109-97-7 pyrrole 
• 103-80-0 phenylacetyl chloride 
• 100-39-0 benzyl bromide 
• 117067-98-8 α-(dimethylamino)-α-(pyrrol-2-yl)acetonitrile 
• 103-82-2 phenylacetic acid 
• 857426-52-9 2-phenyl-1-pyrrol-2-yl-ethanol 
• 17123-83-0 N-(phenylacetyl)morpholine 
• 14989-30-1 hypochloric acid 
• 103872-45-3 1-(tert-butyldimethylsilyl)-1H-pyrrole 

Downstream Products

• 857426-52-9 2-phenyl-1-pyrrol-2-yl-ethanol 
• 94210-68-1 2,3-Diphenyl-1-oxo-1H-pyrrolizin 
• 92454-16-5 2-(2-phenylethyl)pyrrole 
• 86012-92-2 1-(1-Methyl-1H-pyrrol-2-yl)-2-phenylethanol 
• 96999-25-6 2-Benzo[1,3]dioxol-5-ylmethyl-5-phenethyl-1H-pyrrole 
• 93363-39-4 2-(3,4-methylenedioxybenzoyl)-5-(2-phenylethyl)pyrrole 
• 35563-07-6 2-((E)-2-phenylethen-1-yl)pyrrole 

Relevant articles and documents

Practical Cu(OAc)2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile

We reported a ligand-and additive-free Cu(OAc)2/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary and secondary benzylic alcohols, primary and secondary 1-heteroaryl alcohols, cinnamyl alcohols, and aliphatic alcohols to the corresponding aldehydes and ketones. This ambient temperature oxidation protocol is of practical features like aqueous acetonitrile as solvent, ambient air as the terminal oxidant, and low catalyst loading, presenting a potential value in terms of both economical and environmental considerations. Based on the experimental observations, a plausible reaction mechanism was proposed.

Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide

A highly efficient procedure for preparing 2-acylpyrroles and its derivatives is described. The products were obtained through regioselective Friedel-Crafts reactions of pyrroles and its derivatives with alkyl or aryl acid chlorides catalysed by zinc oxide under solvent-free conditions. This method has the advantages of green chemistry, operational simplicity, solvent-free conditions, and recoverable catalyst.

Friedel-Crafts acylation of arenes with carboxylic acids using silica gel supported AlCl3

Aromatic compounds react smoothly with carboxylic acids in the presence of silica gel supported aluminium trichloride to afford the corresponding ketones with high regioselectivity in high to excellent yields. The catalyst is stable (as a bench top catalyst) and can be easily recovered and reused without appreciable change in its efficiency. tuebitak.

±2-[Phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine antihypertensives and use thereas

A compound of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof are potent antihypertensive agents and are therefore useful as cardiovascular system regulators.

FRIEDEL-CRAFTS ACYLATION OF 1-TERT-BUTYLDIMETHYLSILYLPYRROLE, A VERY SHORT AND SIMPLE ROUTE TO 3-SUBSTITUTED PYRROLES.

1-tert-Butyldimethylsilylpyrrole undergoes Friedel-Crafts acylation almost exclusively at β-position giving after sodium fluoride supported hydrolysis the 3-pyrroloketones.

Synthesis of Alkylpyrroles by the Sodium Borohydride Reduction of Acylpyrroles

N-Unsubstituted alkylpyrroles are obtained by the reduction of the corresponding acylpyrroles with sodium borohydride in boiling 2-propanol.This reaction was demonstrated to proceed via the pyrrolylalkylcarbinol and was extended to the synthesis of a branched chain alkylpyrrole 25 from the tertiary alcohol 24.

Zur Reaktion von Cyclopropenonen mit Azomethinen; VII. Diphenylcyclopropenon und cyclische Amidine: Synthese von bi- und tricyclischen Pyrrolinon-Derivaten

Reaction of diphenylcyclopropenone (1) with cyclic amidines 2 or 10-13 gives rise to bi- and tricyclic pyrrolinone derivatives of different structural types (3 or 14-17), which can be transformed in simple sequences to pyrrolinone-annellated heterobi- and -tricyclic compounds (7, 18-21).