35563-07-6

Upstream product

• 103-80-0 phenylacetyl chloride 
• 108-86-1 bromobenzene 
• 180283-59-4 1,1-dimethylethyl 2-ethenyl-1H-pyrrole-1-carboxylate 
• 1003-29-8 2-pyrrole aldehyde 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 857426-52-9 2-phenyl-1-pyrrol-2-yl-ethanol 
• 161282-57-1 N-tert-butoxycarbonylpyrrole-2-carboxaldehyde 
• 20767-31-1 benzyl(triphenyl)phosphonium bromide 
• 1939-99-7 benzenesulfonyl chloride 
• 141-52-6 sodium ethanolate 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 100-51-6 benzyl alcohol 
• 13169-74-9 2-phenyl-1-(1H-pyrrol-2-yl)ethanone 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 2761-76-4 cis-2-styrylpyrrole 
• 147962-52-5 2-formyl-5-((E)-2-phenylethen-1-yl)pyrrole 
• 345312-03-0 3,5-distyryl-8-phenyl-difluoroboradiaza-s-indacene 
• 345312-02-9 3,5-distyryl-8-(p-dimethylaminophenyl)-difluoroboradiaza-s-indacene 
• 1383828-34-9 C₁₅H₂₁N₂O₃P 
• 110461-20-6 1-phenyl-2-(1H-pyrrol-2-yl)ethane-1,2-dione 
• 106904-11-4 (Z)-methyl 3-methoxy-2-[(E)-2-styrylpyrrol-1-yl]acrylate 
• 92454-16-5 2-(2-phenylethyl)pyrrole 

Relevant academic research and scientific papers

Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal-organic photodynamic therapy

A new family of ten dinuclear Ru(ii) complexes based on the bis[pyrrolyl Ru(ii)] triad scaffold, where two Ru(bpy)2 centers are separated by a variety of organic linkers, was prepared to evaluate the influence of the organic chromophore on the spectroscopic and in vitro photodynamic therapy (PDT) properties of the compounds. The bis[pyrrolyl Ru(ii)] triads absorbed strongly throughout the visible region, with several members having molar extinction coefficients (?) ≥ 104 at 600-620 nm and longer. Phosphorescence quantum yields (Φp) were generally less than 0.1% and in some cases undetectable. The singlet oxygen quantum yields (ΦΔ) ranged from 5% to 77% and generally correlated with their photocytotoxicities toward human leukemia (HL-60) cells regardless of the wavelength of light used. Dark cytotoxicities varied ten-fold, with EC50 values in the range of 10-100 μM and phototherapeutic indices (PIs) as large as 5400 and 260 with broadband visible (28 J cm-2, 7.8 mW cm-2) and 625 nm red (100 J cm-2, 42 mW cm-2) light, respectively. The bis[pyrrolyl Ru(ii)] triad with a pyrenyl linker (5h) was especially potent, with an EC50 value of 1 nM and PI > 27 000 with visible light and subnanomolar activity with 625 nm light (100 J cm-2, 28 mW cm-2). The lead compound 5h was also tested in a tumor spheroid assay using the HL60 cell line and exhibited greater photocytotoxicity in this more resistant model (EC50 = 60 nM and PI > 1200 with 625 nm light) despite a lower dark cytotoxicity. The in vitro PDT effects of 5h extended to bacteria, where submicromolar EC50 values and PIs >300 against S. mutans and S. aureus were obtained with visible light. This activity was attenuated with 625 nm red light, but PIs were still near 50. The ligand-localized 3ππ? state contributed by the pyrenyl linker of 5h likely plays a key role in its phototoxic effects toward cancer cells and bacteria. This journal is

Design of fluorescent probes with optimized responsiveness and selectivity to GSH

We designed and synthesized a series of BODIPY based probes with fast and distinct ratiometric responsiveness for discriminative detection of GSH from Cys and Hcy. The discriminative detection is based on the different products obtained by the SNAr between probes and thiol-containing amino acids. The amino group of the obtained thioether from the reaction with Cys or Hcy but not GSH would trigger an intramolecular nucleophilic substitution through five- or six-membered cyclic transition state, finally yielding an amino substituted derivative. To achieve highly discriminative detection and fast response, a series of structure modifications and improvements have been made by elongating the π-conjugation and introducing electron withdrawing groups, finally affording probe BOD-DBNPF with optimized responsiveness and selectivity. Importantly, BOD-DBNPF was successfully used for the selective detection of GSH from Cys with distinct fluorescent ratiometric responses in living HeLa cells.

Use of nitrogen-containing heterocyclic radical substituted alkene compounds

The invention relates to new use of a series of nitrogen-containing heterocyclic radical substituted alkene compounds, and more specifically relates to use of the compounds represented by general formula a or salts thereof in bioimaging, pH value detection, biomacromolecule detection or cell microenvironment detection, wherein Z, S1, S2 and R1 are defined as the specification. The compounds are utilized as the fluorescent dye for bioimaging, fluorescent pH probe for pH value detection and/or diagnostic agent for tumor cell detection. The compounds involved in the invention have excellent imaging effect, and shows the single component multicolor property, can be used for single component multicolor imaging or conventional imaging, etc., and haves enormous application prospect in bioimaging and tumor detection. (formula a).

Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemical reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

A continuous visible light spectrophotometric approach to accurately determine the reactivity of radical-trapping antioxidants

Inhibited autoxidations-monitored either by O2 consumption or hydroperoxide formation-are the most reliable way to obtain kinetic and stoichiometric information on the activity of radical-trapping antioxidants (RTAs). While many comparatively simple "antioxidant assays" (e.g., the DPPH assay) have supplanted these in popularity, they are generally very poor substitutes since they often do not employ peroxyl radicals as the oxidant and do not account for both the kinetics and stoichiometry of the radical-trapping reaction(s). In an effort to make inhibited autoxidations as simple as the most popular "antioxidant assays", we have developed a spectrophotometric approach for monitoring reaction progress in inhibited autoxidations. The approach employs easily prepared 1-phenylbutadiene-conjugated or styrene-conjugated BODIPY chromophores (PBD-BODIPY or STY-BODIPY, respectively) as signal carriers that co-autoxidize along with a hydrocarbon substrate. We show that inhibition rate constants (kinh) are accurately determined for a range of phenolic and diarylamine RTAs using this approach and that mechanistic experiments, such as kinetic isotope effects and kinetic solvent effects, are equally easily carried out. Moreover, synergistic interactions between RTAs, as well as the unconventional activity of diarylamine RTAs, are captured using this methodology. Lastly, we show that the approach can be employed for monitoring reactions in aqueous solution.

Coordinatively immobilized monolayers on porous coordination polymer crystals

Surface-specific: Coordinatively immobilized monolayers (CIMs) of fluorescent dyes were fabricated on specific single-crystal surfaces of porous coordination polymers (PCPs) (see picture). This approach enables the fabrication of functional PCP crystal su

Microwave-assisted, aqueous wittig reactions: Organic-solvent- And protecting-group-free chemoselective synthesis of functionalized alkenes

(Chemical Equation Presented) Free from protection! A general, chemoselective, protecting-group- and organic-solvent-free route to stilbenes and heterostilbenes involving the direct synthesis of triethyl benzylic and allylic phosphonium salts from the corresponding alcohols and their microwave-assisted, aqueous Wittig reactions is described.

The triphenyl phosphite-chlorine reagent in the synthesis of pyrroles from N-allylamides

A novel application of (PhO)3P-Cl2 chemistry to the synthesis of 2-substituted and 2,3-disubstituted pyrroles from N-allyl-amides is illustrated. A mild procedure is used to generate the imino chloride intermediates, which are subseq

Heterocyclic compounds as fungicides

Fungicidally active compounds of the formula STR1 and steroisomers thereof, wherein A is the group =CW--or a nitrogen atom, B is the group =CX--or a nitrogen atom, D is the group =CY--or a nitrogen atom, and E is the group =CZ--or a nitrogen atom, wherein

SYNTHESIS AND PHOTOCHEMICAL BEHAVIOUR OF SUBSTITUTED ETHYLENES; PYRROLE AND INDOLE DERIVATIVES

The trans isomers of three (3-indolyl)arylethylenes have been synthesized by a Perkin-type reaction.The corresponding isomers were obtained by photoisomerization. 2-styrylpyrrole in both the trans and cis forms was synthesized by a Wittig reaction.The spectral characteristics and photochemical behaviour of the synthesized compounds are reported.