132213-07-1

Basic information

• Product Name: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine
• Synonyms: IMidazo(1,2-a)pyridine-6-ylMethanol;IMidazo[1,2-a]pyridine-6-Methanol;(H-iMidazo[1,2-a]pyridin-6-yl)Methanol;6-(Hydroxymethyl)imidazo[1,2-a]pyridine97%;IMIDAZO[1,2-A]PYRIDIN-6-YLMETHANOL;6-(Hydroxymethyl)imidazo[1,2-a]pyridine;6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%
• CAS NO: 132213-07-1
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Mol File: 132213-07-1.mol

Chemical Properties

• Melting Point: 105-107
• Appearance: /
• Density: 1.267 g/cm³
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.36±0.10(Predicted)
• CAS DataBase Reference: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(132213-07-1)
• EPA Substance Registry System: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(132213-07-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 132213-07-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-(Hydroxymethyl)imidazo[1,2-a]pyridine is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and resonance properties allow it to participate in a range of chemical reactions, making it a valuable component in the creation of new molecules and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-(Hydroxymethyl)imidazo[1,2-a]pyridine is used as a building block for the development of new drugs. Its ability to form stable complexes with other molecules makes it a promising candidate for the design of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug discovery.
Used in Chemical Research:
6-(Hydroxymethyl)imidazo[1,2-a]pyridine is employed as a research tool in chemical laboratories, where it is used to study the properties and behavior of heterocyclic aromatic compounds. Its resonance characteristics and reactivity with other chemicals make it an important subject of investigation for understanding the fundamental principles of organic chemistry and the development of new synthetic strategies.
Used in Material Science:
6-(Hydroxymethyl)imidazo[1,2-a]pyridine is utilized in the field of material science for the development of new materials with unique properties. Its incorporation into polymers and other materials can lead to the creation of novel composites with enhanced characteristics, such as improved stability, conductivity, or reactivity.
Used in Environmental Applications:
Although information on the toxicity and ecological impacts of 6-(Hydroxymethyl)imidazo[1,2-a]pyridine is limited, it may be used in environmental applications where its chemical properties can be harnessed for the remediation of pollutants or the development of eco-friendly materials. Further research is needed to fully understand its potential in this area and to ensure its safe and responsible use.

InChI:InChI=1/C8H8N2O/c11-6-7-1-2-8-9-3-4-10(8)5-7/h1-5,11H,6H2

Upstream product

• 139022-25-6 imidazo[1,2-a]pyridine-6-carboxylic acid 
• 136117-69-6 methyl 6-imidazo<1,2-a>pyridinecarboxylate 
• 36052-24-1 methyl 6-aminonicotinoate 
• 329-89-5 6-aminonicotinic amide 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 158001-04-8 imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester 
• 107-20-0 2-chloroethanal 
• 113293-71-3 (6-amino-3-pyridinyl)methanol 

Downstream Products

• 1196072-10-2 TH-1435 
• 372147-65-4 (Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-6-yl)propenoate 
• 167884-21-1 (3-chloroimidazo[1,2-a]pyridin-6-yl)methanol 
• 1004550-21-3 (3-fluoroimidazo[1,2-a]pyridin-6-yl)methanol 
• 1004550-19-9 (3-bromoimidazo[1,2-a]pyridin-6-yl)methanol 
• 116355-16-9 6-imidazo<1,2-a>pyridinecarboxaldehyde 
• 132213-03-7 imidazo<1,2-a>pyridin-6-ylmethylamine 

Relevant articles and documents

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Fragment based discovery of a novel and selective PI3 kinase inhibitor

We report the use of fragment screening and fragment based drug design to develop a PI3c kinase fragment hit into a lead. Initial fragment hits were discovered by high concentration biochemical screening, followed by a round of virtual screening to identify additional ligand efficient fragments. These were developed into potent and ligand efficient lead compounds using structure guided fragment growing and merging strategies. This led to a potent, selective, and cell permeable PI3c kinase inhibitor with good metabolic stability that was useful as a preclinical tool compound.

NOVEL FUSED IMIDAZOLE DERIVATIVE

The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A1 and A2, are each a nitrogen atom, and the like; X2, X3, X4, and X5 are all carbon atoms, or alternatively any one of X2, X3, X4, and X5 is a nitrogen atom and the rest are all carbon atoms; R1 is a hydrogen atom, or the like; R2, R3, R4, and R5, are each a hydrogen atom, or the like; R6 and R6', are each a hydrogen atom, and the like; R7 is an aryl group and the like; and R8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines was explored experimentally and theoretically using semiempirical AM1 and ab initio methods. A range of functionalized vinylic derivatives (azido, amino, and carbodiimide groups) were prepared for conversion into pyrroloazaindoles 19-22, imidazo[1,x]-; (x=5, 6, 7, 8), [2,6]-, and [2,7]naphthyridines 28-30, 35-38 by thermal reaction. In the case of vinylic groups in the 5 position, peri annulation also was observed. The experimental and theoretical data are compared and discussed.

Thioformamide derivatives

The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: [Figure] wherein Y represents [Figure] or the like [wherein R7 represents benzyloxy or the like; R11 and R12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, [Figure] (wherein R14 and R15 each represent hydrogen, benzyl or the like) or the like]; Z represents --CH2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R1 and R2 each represent hydrogen, lower alkyl or the like; and R3 and R4 each represent hydrogen, lower alkyl or the like.

The photosolvolysis of N-arylmethyladenines. Photoremovable N-arylmethyl protective groups for N-containing compounds

N-arylmethyladenines are photolyzed in water, giving adenine and the corresponding arylmethanols.The reaction is not only observed when the arylmethyl group is a metasubstituted benzyl, but also with more complex substituents like imidazopyridin-6-ylmethyl.Meta-substituted arylmethyl groups are proposed as photoremovable N-protective groups in adenine chemistry.