132213-07-1

Basic information

• Product Name: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine
• Synonyms: IMidazo(1,2-a)pyridine-6-ylMethanol;IMidazo[1,2-a]pyridine-6-Methanol;(H-iMidazo[1,2-a]pyridin-6-yl)Methanol;6-(Hydroxymethyl)imidazo[1,2-a]pyridine97%;IMIDAZO[1,2-A]PYRIDIN-6-YLMETHANOL;6-(Hydroxymethyl)imidazo[1,2-a]pyridine;6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%
• CAS NO: 132213-07-1
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Mol File: 132213-07-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 105-107
• Appearance: /
• Density: 1.267 g/cm³
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.36±0.10(Predicted)
• CAS DataBase Reference: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(132213-07-1)
• EPA Substance Registry System: 6-(Hydroxymethyl)imidazo[1,2-a]pyridine(132213-07-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 132213-07-1(Hazardous Substances Data)

Usage

General Description

6-(Hydroxymethyl)imidazo[1,2-a]pyridine, also known as CAS Number 1064896-97-8, is a chemical compound belonging to the heterocyclic aromatic compound family. It is primarily used in organic synthesis and as a building-block in various chemical reactions. The molecular formula is C8H8N2O and it has a molecular weight of 148.16 g/mol. Like other aromatic compounds with a nitrogen base, it is notable for its resonance properties, which allow it to interact in varied ways with other chemicals. However, little information is available about its toxicity or potential ecological impacts.

InChI:InChI=1/C8H8N2O/c11-6-7-1-2-8-9-3-4-10(8)5-7/h1-5,11H,6H2

Upstream product

• 107-20-0 2-chloroethanal 
• 113293-71-3 (6-amino-3-pyridinyl)methanol 
• 158001-04-8 imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester 
• 39658-41-8 ethyl-6-amino-nicotinate 
• 329-89-5 6-aminonicotinic amide 
• 36052-24-1 methyl 6-aminonicotinoate 
• 136117-69-6 methyl 6-imidazo<1,2-a>pyridinecarboxylate 
• 139022-25-6 imidazo[1,2-a]pyridine-6-carboxylic acid 

Downstream Products

• 132213-03-7 imidazo<1,2-a>pyridin-6-ylmethylamine 
• 116355-16-9 6-imidazo<1,2-a>pyridinecarboxaldehyde 
• 1196072-10-2 TH-1435 
• 372147-65-4 (Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-6-yl)propenoate 
• 167884-21-1 (3-chloroimidazo[1,2-a]pyridin-6-yl)methanol 
• 1004550-21-3 (3-fluoroimidazo[1,2-a]pyridin-6-yl)methanol 
• 1004550-19-9 (3-bromoimidazo[1,2-a]pyridin-6-yl)methanol 

Relevant articles and documents

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

NOVEL FUSED IMIDAZOLE DERIVATIVE

The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A1 and A2, are each a nitrogen atom, and the like; X2, X3, X4, and X5 are all carbon atoms, or alternatively any one of X2, X3, X4, and X5 is a nitrogen atom and the rest are all carbon atoms; R1 is a hydrogen atom, or the like; R2, R3, R4, and R5, are each a hydrogen atom, or the like; R6 and R6', are each a hydrogen atom, and the like; R7 is an aryl group and the like; and R8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.

Thioformamide derivatives

The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: [Figure] wherein Y represents [Figure] or the like [wherein R7 represents benzyloxy or the like; R11 and R12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, [Figure] (wherein R14 and R15 each represent hydrogen, benzyl or the like) or the like]; Z represents --CH2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R1 and R2 each represent hydrogen, lower alkyl or the like; and R3 and R4 each represent hydrogen, lower alkyl or the like.