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132213-07-1

132213-07-1

Identification

Synonyms:IMIDAZO[1,2-A]PYRIDIN-6-YLMETHANOL;6-(Hydroxymethyl)imidazo[1,2-a]pyridine;6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%;IMidazo(1,2-a)pyridine-6-ylMethanol;IMidazo[1,2-a]pyridine-6-Methanol;(H-iMidazo[1,2-a]pyridin-6-yl)Methanol

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
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  • Purchase
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%
  • Packaging:250 mg
  • Price:$ 42
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%
  • Packaging:1 g
  • Price:$ 119
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%
  • Packaging:5 g
  • Price:$ 493
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 95+%
  • Packaging:5g
  • Price:$ 607
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 95+%
  • Packaging:10g
  • Price:$ 998
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 95+%
  • Packaging:1g
  • Price:$ 197
  • Delivery:In stock
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  • Manufacture/Brand:J&W Pharmlab
  • Product Description:Imidazo[1,2-a]pyridin-6-yl-methanol 96%
  • Packaging:100mg
  • Price:$ 85
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 97%
  • Packaging:5g
  • Price:$ 383
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 95+%
  • Packaging:10g
  • Price:$ 945
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:Imidazo[1,2-a]pyridin-6-ylmethanol 95+%
  • Packaging:250mg
  • Price:$ 53
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Relevant articles and documentsAll total 6 Articles be found

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

-

Paragraph 00530-00531, (2015/05/19)

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

NOVEL FUSED IMIDAZOLE DERIVATIVE

-

Page/Page column 80, (2010/11/28)

The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A1 and A2, are each a nitrogen atom, and the like; X2, X3, X4, and X5 are all carbon atoms, or alternatively any one of X2, X3, X4, and X5 is a nitrogen atom and the rest are all carbon atoms; R1 is a hydrogen atom, or the like; R2, R3, R4, and R5, are each a hydrogen atom, or the like; R6 and R6', are each a hydrogen atom, and the like; R7 is an aryl group and the like; and R8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.

Thioformamide derivatives

-

, (2008/06/13)

The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: [Figure] wherein Y represents [Figure] or the like [wherein R7 represents benzyloxy or the like; R11 and R12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, [Figure] (wherein R14 and R15 each represent hydrogen, benzyl or the like) or the like]; Z represents --CH2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R1 and R2 each represent hydrogen, lower alkyl or the like; and R3 and R4 each represent hydrogen, lower alkyl or the like.

Process route upstream and downstream products

Process route

imidazo[1,2-a]pyridine-6-carboxylic acid
139022-25-6

imidazo[1,2-a]pyridine-6-carboxylic acid

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 80 ℃; for 3.5h;
26%
imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester
158001-04-8

imidazo[1,2-a]pyridine-6-carboxylic acid ethyl ester

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h;
62%
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 25 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 3.5 h / 0 - 80 °C
With lithium hydroxide monohydrate; dimethylsulfide borane complex; In tetrahydrofuran; water;
methyl 6-imidazo<1,2-a>pyridinecarboxylate
136117-69-6

methyl 6-imidazo<1,2-a>pyridinecarboxylate

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;
32%
ethyl-6-amino-nicotinate
39658-41-8

ethyl-6-amino-nicotinate

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 93 percent / NaHCO3 / ethanol; H2O / 9 h / Heating
2: 62 percent / LiAlH4 / tetrahydrofuran / 3 h
With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;
Multi-step reaction with 2 steps
1: LiAlH4
With lithium aluminium tetrahydride;
methyl 6-aminonicotinoate
36052-24-1

methyl 6-aminonicotinoate

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / methanol / 8 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol;
6-aminonicotinic amide
329-89-5

6-aminonicotinic amide

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: H(+)
2: LiAlH4
With lithium aluminium tetrahydride; hydrogen cation;
2-chloroethanal
107-20-0

2-chloroethanal

(6-amino-3-pyridinyl)methanol
113293-71-3

(6-amino-3-pyridinyl)methanol

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

Conditions
Conditions Yield
57%
TH-1152
1196071-97-2

TH-1152

6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

TH-1435
1196072-10-2

TH-1435

Conditions
Conditions Yield
With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 20 ℃;
6-(hydroxymethyl)imidazo[1,2-a]pyridine
132213-07-1

6-(hydroxymethyl)imidazo[1,2-a]pyridine

N-((3-(3-((dimethylamino)methyl)phenyl)imidazo[1,2-a]pyridin-6-yl)methyl)-N-methyl-5-(3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridin-2-yl)-1,3,4-oxadiazol-2-amine

N-((3-(3-((dimethylamino)methyl)phenyl)imidazo[1,2-a]pyridin-6-yl)methyl)-N-methyl-5-(3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridin-2-yl)-1,3,4-oxadiazol-2-amine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: N-Bromosuccinimide; acetonitrile / 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 80 °C
3: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 3 h / 100 °C
4: sodium tris(acetoxy)borohydride / tetrahydrofuran; dichloromethane / 2.5 h / 20 °C
With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); sodium tris(acetoxy)borohydride; caesium carbonate; acetonitrile; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

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