13343-40-3

Basic information

• Product Name: 1,1-DIFLUORO-2-PHENYL-CYCLOPROPANE
• Synonyms: 1,1-DIFLUORO-2-PHENYL-CYCLOPROPANE;(2,2-Difluorocyclopropyl)benzene
• CAS NO: 13343-40-3
• Molecular Formula: C₉H₈F₂
• Molecular Weight: 154.16
• Mol File: 13343-40-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1-DIFLUORO-2-PHENYL-CYCLOPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIFLUORO-2-PHENYL-CYCLOPROPANE(13343-40-3)
• EPA Substance Registry System: 1,1-DIFLUORO-2-PHENYL-CYCLOPROPANE(13343-40-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 13343-40-3(Hazardous Substances Data)

Usage

Structure

Fluorinated cyclopropane derivative with a phenyl group attached to the cyclopropane ring

Application

Used in organic synthesis and medicinal chemistry

Reactivity

Unique reactivity due to its molecular structure and fluorine substituents

Pharmaceutical Applications

Potential pharmaceutical applications

Building Block

Valuable building block for creating new compounds with diverse properties and biological activities

Stability

Enhanced stability due to the presence of fluorine atoms

Resistance

Resistance to metabolic degradation, making it a valuable tool for drug discovery research

Upstream product

• 100-42-5 styrene 
• 24925-18-6 phenyl(trifluoromethyl)mercury 
• 5863-80-9 tris(trifluoromethyl)bismuth 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 428-59-1 Hexafluoropropene oxide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 
• 75-61-6 dibromodifluoromethane 
• 754-25-6 trimethyl(trifluoromethyl)tin 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 77197-63-8 1-phenyl-2-n-butylcyclopropene 
• 24168-52-3 1,2-Diphenylcyclopropen 
• 100-42-5 styrene 

Relevant articles and documents

Synthesis of gem-Difluorocyclopropanes in a Phase-transfer Catalysed System

Reaction of CH2Br2 with CBr2F2 and alkenes 1a-e in the presence of 60percent aqueous KOH and tetrabutylammonium hydrogensulphate as a catalyst affords gem-difluorocyclopropanes 2a-e.

Sodium trifluoroacetate: An efficient difluorocarbene precursor for alkenes

A novel and efficient difluorocarbene precursor was achieved. In a convenient procedure, a variety of alkenes could be gem-difluorocyclopropanated with sodium trifluoroacetate to give the corresponding products in moderate to high yields, using azobisisob

Rhodium Catalyzed Regioselective C?H Allylation of Simple Arenes via C?C Bond Activation of Gem-difluorinated Cyclopropanes

Herein, we report a rhodium catalyzed directing-group free regioselective C?H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C?C and C?F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodology enables facile late-stage functionalization of complex bioactive molecules. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments. Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes.

Three-component reaction ofgem-difluorinated cyclopropanes with alkenes and B2pin2for the synthesis of monofluoroalkenes

Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by usinggem-difluorinated cyclopropanes and