134256-32-9

Basic information

• Product Name: N-benzyl-2-(2-hydroxyethyl)piperidine
• CAS NO: 134256-32-9
• Molecular Weight: 219.327
• Mol File: 134256-32-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-(2-hydroxyethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(2-hydroxyethyl)piperidine(134256-32-9)
• EPA Substance Registry System: N-benzyl-2-(2-hydroxyethyl)piperidine(134256-32-9)

Safety Data

• Hazardous Substances Data: 134256-32-9(Hazardous Substances Data)

Upstream product

• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 100-39-0 benzyl bromide 
• 98-88-4 benzoyl chloride 
• 34418-91-2 2,3,4,5-tetrahydropyridine N-oxide 
• 106968-19-8 (S)-2 
• 134256-17-0 (R)-2,2-dimethyl-1-phenylpropyl vinyl ether 
• 100-44-7 benzyl chloride 
• 119204-12-5 2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine 
• 110-89-4 piperidine 
• 119204-19-2 (2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide 
• 19774-49-3 1-phenyloctahydropyrido[1,2-c][1,3]oxazine 
• 77034-34-5 ethyl N-benzylpipecolinate 
• 22722-98-1 sodium bis(2-methoxyethoxy)aluminium dihydride 

Downstream Products

• 19774-49-3 1-phenyloctahydropyrido[1,2-c][1,3]oxazine 
• 120014-06-4 donepezil 
• 145546-80-1 (E)-2-((1-benzylpiperidine-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 
• 78944-63-5 C₁₄H₂₁NO₂ 
• 136704-11-5 1-benzyl-2-(2-chloroethyl)piperidine hydrochloride 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 132525-81-6 O-2-(1-benzyl-2-piperidyl)ethyl O-phenyl thionocarbonate 
• 132525-84-9 O-2-(1-benzyl-2-piperidyl)ethyl S-phenyl dithionocarbonate 
• 1393836-97-9 2-[1-benzyl-2-((indan-2-yl)(thiazol-2-yl)amino)ethyl]piperidine 
• 1393836-96-8 2-[1-benzyl-2-((indan-2-yl)amino)ethyl]piperidine 
• 1025909-53-8 (1-benzylpiperidin-2-yl)acetaldehyde 
• 132525-85-0 1-benzyl-4-phenylthiooctahydroazocine 
• 132525-82-7 1-benzyl-4-phenoxyoctahydroazocine 
• 132525-83-8 1-benzyl-2-(2-phenoxyethyl)piperidine 

Relevant articles and documents

Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe Alzheimer's disease. Two series of analogues were prepared, the first looking at the replacement of the piperidine ring in donepezil with different sized saturated N-containing ring systems and the second looking at the introduction of different linkers between the indanone and piperidine rings in donepezil. The most active analogue 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl 1-benzylpiperidine-4-carboxylate (67) afforded an in vitro IC50value of 0.03 ± 0.07 μM against acetylcholinesterase with no cytotoxicity observed (IC50of >100 μM, SH-SY5Y cell line). In comparison donepezil had an IC50of 0.05 ± 0.06 μM and an observed cytotoxicity IC50of 15.54 ± 1.12 μM. Molecular modelling showed a strong correlation between activity and in silico binding in the active site of acetylcholinesterase.

Aminoindane Compounds and Use Thereof in Treating Pain

The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.

Novel application of electrooxidative method for the cyclization of N-benzyl-2-(hydroxymethyl)-and N-benzyl-2-(2-hydroxyethyl)piperidines

Several novel 1,3-oxazinane and oxazolidine derivatives were obtained from the corresponding N-benzyl-2-(2-hydroxyethyl)-and N-benzyl-2-(hydroxymethyl) piperidines via electrochemical oxidation. The reactions were carried out in methanol under basic conditions. The yields of the cyclic products were significantly improved using catalytic amounts of iodide ions, which presumably act as effective electron carriers in the two-electron oxidation process. The Japan Institute of Heterocyclic Chemistry.