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139163-43-2

139163-43-2

Identification

Synonyms:L-Valine,3-methyl-, hydrochloride (9CI);L-tert-Leucine hydrochloride;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:H-Tle-OH.HCl
  • Packaging:500mg
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:(S)-2-Amino-3,3-dimethylbutanoicacidhydrochloride 95+%
  • Packaging:5g
  • Price:$ 646
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:L-TERT-LEUCINE HYDROCHLORIDE 95.00%
  • Packaging:5MG
  • Price:$ 495.89
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:L-TERT-LEUCINE HYDROCHLORIDE 95.00%
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  • Price:$ 700
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  • Manufacture/Brand:Ambeed
  • Product Description:(S)-2-Amino-3,3-dimethylbutanoicacidhydrochloride 95+%
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  • Price:$ 17
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  • Manufacture/Brand:Ambeed
  • Product Description:(S)-2-Amino-3,3-dimethylbutanoicacidhydrochloride 95+%
  • Packaging:100g
  • Price:$ 174
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  • Manufacture/Brand:Ambeed
  • Product Description:(S)-2-Amino-3,3-dimethylbutanoicacidhydrochloride 95+%
  • Packaging:25g
  • Price:$ 60
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Relevant articles and documentsAll total 6 Articles be found

Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging α-Amino Acids

Nian, Yong,Wang, Jiang,Zhou, Shengbin,Wang, Shuni,Moriwaki, Hiroki,Kawashima, Aki,Soloshonok, Vadim A.,Liu, Hong

supporting information, p. 12918 - 12922 (2015/11/02)

Structurally simple and inexpensive chiral tridentate ligands were employed for substantially advancing the purely chemical dynamic kinetic resolution (DKR) of unprotected racemic tailor-made α-amino acids (TM-α-AAs), enabling the first DKR of TM-α-AAs bearing tertiary alkyl chains as well as multiple unprotected functional groups. Owing to the operationally convenient conditions, virtually complete stereoselectivity, and full recyclability of the source of chirality, this method should find wide applications for the preparation of TM-α-AAs, especially on large scale. The non-enzymatic dynamic kinetic resolution of racemic α-amino acids bearing tertiary alkyl chains and multiple unprotected functional groups is based on the enantioselective formation of nickel(II) complexes and their hydrolysis under convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled.

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE

-

, (2012/10/08)

Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.

Catalytic asymmetric acylcyanation of imines

Pan, Subhas Chandra,Zhou, Jian,List, Benjamin

, p. 612 - 614 (2008/02/01)

(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desire

Process route upstream and downstream products

Process route

C<sub>13</sub>H<sub>19</sub>NO<sub>2</sub>*HCl

C13H19NO2*HCl

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 8h; under 760.051 Torr;
98%
(S)-(+)-2-amino-3,3-dimethylbutanamide
62965-57-5

(S)-(+)-2-amino-3,3-dimethylbutanamide

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; water; for 24h; Heating / reflux;
85%
<i>N</i>-benzyl-<i>N</i>-(1-cyano-2,2-dimethyl-propyl)-acetamide
929220-40-6

N-benzyl-N-(1-cyano-2,2-dimethyl-propyl)-acetamide

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 96 percent / sulfuric acid / H2O / 16 h / 45 °C
2: 98 percent / aq. HCl / 6 h / 100 °C
3: 98 percent / hydrogen / palladium on carbon / methanol / 8 h / 20 °C / 760.05 Torr
With hydrogenchloride; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; water;
C<sub>15</sub>H<sub>21</sub>NO<sub>3</sub>
929220-45-1

C15H21NO3

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 98 percent / aq. HCl / 6 h / 100 °C
2: 98 percent / hydrogen / palladium on carbon / methanol / 8 h / 20 °C / 760.05 Torr
With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;
N-(2,2-dimethylpropylidene)benzylamine
1775-74-2

N-(2,2-dimethylpropylidene)benzylamine

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: chiral 1,2-diaminocyclohexane based reagent / toluene / -40 °C
2: 96 percent / sulfuric acid / H2O / 16 h / 45 °C
3: 98 percent / aq. HCl / 6 h / 100 °C
4: 98 percent / hydrogen / palladium on carbon / methanol / 8 h / 20 °C / 760.05 Torr
With hydrogenchloride; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; water; toluene;
L-tert-leucine dibenzoyl-d-tartrate salt

L-tert-leucine dibenzoyl-d-tartrate salt

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 12h;
L-tert-leucine dibenzoyl-D-tartrate

L-tert-leucine dibenzoyl-D-tartrate

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In water; for 12h;
C<sub>31</sub>H<sub>30</sub>Cl<sub>3</sub>N<sub>3</sub>NiO<sub>3</sub>

C31H30Cl3N3NiO3

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
With hydrogenchloride; In methanol; water; at 70 ℃; for 2h;
84%
(4S)-2-(2,2-dimethylpropyl)-4-phenyl-4,5-dihydrooxazole

(4S)-2-(2,2-dimethylpropyl)-4-phenyl-4,5-dihydrooxazole

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 84 percent / selenium dioxide / dioxane / 2 h / Heating
2: 82 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
3: 1.) HCl gas, 2.) H2, 3.) conc. HCl / 2.) Pd-C
With hydrogenchloride; selenium(IV) oxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
(5R)-3-tert-butyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one
175226-69-4

(5R)-3-tert-butyl-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride
139163-43-2

(S)-2-amino-3,3-dimethylbutanoic acid hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 82 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / 760 Torr / Ambient temperature
2: 1.) HCl gas, 2.) H2, 3.) conc. HCl / 2.) Pd-C
With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethyl acetate;

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