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1423027-25-1

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1423027-25-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1423027-25-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,3,0,2 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1423027-25:
(9*1)+(8*4)+(7*2)+(6*3)+(5*0)+(4*2)+(3*7)+(2*2)+(1*5)=111
111 % 10 = 1
So 1423027-25-1 is a valid CAS Registry Number.

1423027-25-1Relevant articles and documents

Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction

Pan, Weidong,Lahue, Brian R.,Ma, Yao,Nair, Latha G.,Shipps Jr., Gerald W.,Wang, Yaolin,Doll, Ronald,Bogen, Stéphane L.

, p. 1983 - 1986 (2014/04/17)

The discovery of 3,3-disubstituted piperidine 1 as novel p53-HDM2 inhibitors prompted us to implement subsequent SAR follow up directed towards piperidine core modifications. Conformational restrictions and further functionalization of the piperidine core were investigated as a strategy to gain additional interactions with HDM2. Substitutions at positions 4, 5 and 6 of the piperidine ring were explored. Although some substitutions were tolerated, no significant improvement in potency was observed compared to 1. Incorporation of an allyl side chain at position 2 provided a drastic improvement in binding potency.

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