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1453-81-2

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1453-81-2 Usage

Description

1-Phenyl-1H-1,2,3-triazole is an organic compound characterized by its molecular formula C9H7N3. It is an aromatic azole compound that features a 1,2,3-triazole ring fused with a phenyl group. This versatile chemical is widely utilized in the synthesis of pharmaceuticals, agrochemicals, and materials science, showcasing its importance in various chemical and biochemical applications.

Uses

Used in Pharmaceutical Synthesis:
1-Phenyl-1H-1,2,3-triazole serves as a key intermediate in the development of pharmaceuticals, contributing to the formation of triazolyl-containing compounds that possess potential therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-Phenyl-1H-1,2,3-triazole is employed as a building block for the creation of novel compounds with pesticidal or herbicidal activities, enhancing crop protection and yield.
Used in Materials Science:
1-Phenyl-1H-1,2,3-triazole is utilized in the field of materials science for the synthesis of advanced materials with unique properties, such as those with potential applications in electronics, optics, or as specialty coatings.
Used in Organic Synthesis:
As a versatile component in organic synthesis, 1-Phenyl-1H-1,2,3-triazole is used in the formation of various triazolyl-containing compounds, which can exhibit a range of chemical and biological activities.
Used as a Ligand in Metal-Catalyzed Reactions:
1-Phenyl-1H-1,2,3-triazole also functions as a ligand in metal-catalyzed reactions, facilitating the synthesis of complex organic molecules with improved efficiency and selectivity.
Used in Anticancer Research:
1-Phenyl-1H-1,2,3-triazole has been investigated for its potential biological activities, particularly as a promising anticancer agent. Its study contributes to the discovery of new therapeutic agents for the treatment of various types of cancer.
Overall, 1-Phenyl-1H-1,2,3-triazole is a multifaceted compound with applications spanning across different industries, highlighting its significance in modern chemical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1453-81-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1453-81:
(6*1)+(5*4)+(4*5)+(3*3)+(2*8)+(1*1)=72
72 % 10 = 2
So 1453-81-2 is a valid CAS Registry Number.

1453-81-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-phenyltriazole

1.2 Other means of identification

Product number -
Other names N-phenyl-1,2,3-triazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1453-81-2 SDS

1453-81-2Relevant articles and documents

Phosphorescent cationic iridium(III) complexes with cyclometalating 1H-indazole and 2H-[1,2,3]-triazole ligands

Shavaleev, Nail M.,Scopelliti, Rosario,Graetzel, Michael,Nazeeruddin, Mohammad K.

, p. 84 - 87 (2012)

Two new cationic iridium(III) complexes with cyclometalating 1-phenylindazole or 2-phenyl-1,2,3-triazole ligands, [(C^N)2Ir(4, 4′-di-tert-butyl-2,2′-dipyridyl)](PF6), exhibit yellow or green phosphorescence with quantum yields and ex

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Pallesen, Jakob S.,Narayanan, Dilip,Tran, Kim T.,Solbak, Sara M. ?.,Marseglia, Giuseppe,S?rensen, Louis M. E.,H?j, Lars J.,Munafò, Federico,Carmona, Rosa M. C.,Garcia, Anthony D.,Desu, Haritha L.,Brambilla, Roberta,Johansen, Tommy N.,Popowicz, Grzegorz M.,Sattler, Michael,Gajhede, Michael,Bach, Anders

, p. 4623 - 4661 (2021/05/07)

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants

Targos, Karina,Williams, Oliver P.,Wickens, Zachary K.

supporting information, p. 4125 - 4132 (2021/04/07)

We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts, N-phenylphenothiazine (PTH). This aerobic photochemical reaction engages difficult to oxidize feedstocks, such as benzene, in C(sp2)-N coupling reactions through direct oxidation. Mechanistic studies are consistent with activation of PTH via photooxidation and with Lewis acid cocatalysts scavenging inhibitors inextricably formed in this process.

Cycloaddition Reactions of in situ Generated C2D2 in Dioxane: Efficient Synthetic Approach to D2-Labeled Nitrogen Heterocycles

Voronin, Vladimir V.,Ledovskaya, Maria S.,Rodygin, Konstantin S.,Ananikov, Valentine P.

, p. 5640 - 5648 (2021/11/11)

In this work, an universal synthetic approach for the synthesis of D2-labeled nitrogen heterocycles based on cycloaddition reactions of in situ generated dideuteroacetylene is reported. A key feature of this method is the use of 1,4-dioxane as

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