14639-79-3Relevant articles and documents
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Ramseyer,J. et al.
, p. 347 - 365 (1967)
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Bird,T.G.C. et al.
, p. 65 - 66 (1979)
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Labows et al.
, p. 249,252,254 (1979)
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Bowers,A. et al.
, p. 156 - 161 (1963)
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Preparation method of rocuronium bromide intermediate
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Paragraph 0029-0041, (2021/11/26)
The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of a rocuronium bromide intermediate. To the preparation method, androsterone as shown I is used as a raw material, dehydration reaction is carried out under catalysis of an ecton reagent, and then washing is carried out. To the preparation method, the reaction temperature is reduced -2 - to -17 - 5 α - the byproduct of high-temperature reaction is reduced 40 °C, the reaction liquid is subjected to simple water washing, extraction and concentration to obtain a white solid, and the loss of the main product caused by the recrystallization of the by-product is reduced. The process is simpler, the yield is lower, and the three-waste discharge is less.
Preparation method of rocuronium bromide intermediate 5alpha-sterane-2-ene-17-one
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Paragraph 0009; 0020-0031, (2020/04/02)
The invention discloses a preparation method of a rocuronium bromide intermediate 5alpha-sterane-2-ene-17-one. The specific steps include: sequentially adding epiandrosterone TS, a solvent and a phasetransfer catalyst into a reaction bottle, performing heating to a reaction temperature of 90-120DEG C, carrying out stirring reaction, and conducting post-treatment purification to obtain the 5alpha-sterane-2-ene-17-one. The method provided by the invention greatly shortens the reaction time, reduces byproducts, enhances the yield, reduces three wastes, lowers the production cost, is suitable forindustrial production, and has obvious social and economic benefits.
